Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.
J Clin Pharm Ther. 2010 Aug;35(4):415-9.
Aspirin is considered one of the most prescribed drugs worldwide, predominantly for its cardioprotective effects. However, its use may be precluded by gastrointestinal and haematological side-effects.
To investigate the association between the prophylactic use of aspirin and the prevalence of anaemia among adults. Other demographic factors and co-morbid conditions such as kidney or liver failure, diabetes mellitus, hypertension, hyperlipidemia, coronary artery disease, ulcer, ulcer medications, and the use of non-steroidal anti-inflammatory drugs, which might be associated with anaemia, were also investigated.
No association between aspirin use and prevalence of anaemia was observed. Age and smoking were the only factors contributing significantly to the occurrence of anaemia. Moreover, gender, age and the use of peptic ulcer medication were associated with reduced haemoglobin levels.
The results may help in minimizing concerns about the development of anaemia among patients on aspirin. They highlight the importance of age, gender, smoking and ulcer medication in determining the incidence of anaemia among those patients.
阿司匹林被认为是世界范围内使用最广泛的药物之一，主要因其具有心脏保护作用。然而，其胃肠道和血液学副作用可能会限制其使用。
调查阿司匹林预防性使用与成年人贫血患病率之间的关系。还研究了其他人口统计学因素和合并症，如肾衰竭或肝衰竭、糖尿病、高血压、高血脂、冠心病、溃疡、溃疡药物以及非甾体抗炎药的使用，这些因素可能与贫血有关。
未观察到阿司匹林使用与贫血患病率之间存在关联。年龄和吸烟是导致贫血发生的唯一显著因素。此外，性别、年龄和使用消化性溃疡药物与血红蛋白水平降低有关。
这些结果可能有助于减轻患者对阿司匹林引起贫血的担忧。它们强调了年龄、性别、吸烟和溃疡药物在确定这些患者贫血发生率方面的重要性。
