卡里纳杜榴莲和奥氏杜榴莲树皮中的木脂素和三萜类化合物

Lignans and Triterpenes from the Bark of Durio carinatus and Durio oxleyanus.

作者信息

Lambert Lynette K, Garson Mary J

机构信息

School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.

出版信息

J Nat Prod. 2010 Oct 22;73(10):1649-54. doi: 10.1021/np100332v. Epub 2010 Sep 20.

DOI:10.1021/np100332v

PMID:20853875

Abstract

Investigation of chemical constituents from the bark of Durio carinatus has led to the isolation of three lignans, boehmenan X (1), threo-carolignan X (2), and erythro-carolignan X (3), together with the three known lignans boehmenan, threo-carolignan E, and erythro-carolignan E. The bark of D. oxleyanus yielded two new lignan ethers, threo-carolignan Y (4) and erythro-carolignan Y (5), together with compounds 1, 3, and boehmenan. J-Based configurational analysis and NOE measurements were used to explore conformational issues for the lignan diastereomers, while CD measurements supported an 8'S configuration for the various lignans. The triterpenes 3β-O-cis-caffeoylbetulinic acid and 3β-O-trans-caffeoylbetulinic acid were also characterized from D. carinatus.

摘要

对棱果榴莲树皮的化学成分进行研究后，分离出了三种木脂素，即波希曼X（1）、苏式卡罗木脂素X（2）和赤式卡罗木脂素X（3），以及三种已知的木脂素波希曼、苏式卡罗木脂素E和赤式卡罗木脂素E。奥氏榴莲的树皮产生了两种新的木脂素醚，苏式卡罗木脂素Y（4）和赤式卡罗木脂素Y（5），以及化合物1、3和波希曼。基于J的构型分析和NOE测量用于探索木脂素非对映异构体的构象问题，而圆二色性测量支持各种木脂素的8'S构型。还从棱果榴莲中鉴定出了三萜3β-O-顺式咖啡酰桦木酸和3β-O-反式咖啡酰桦木酸。