Zhang Chun-Lei, Wang Yan, Liu Yan-Fei, Liang Dong, Hao Zhi-You, Luo Huan, Chen Ruo-Yun, Yu De-Quan
Jiangsu Provincial Key Laboratory for TCM Evaluation and Translational Development, School of TCM, China Pharmaceutical University, Nanjing 211198, People's Republic of China; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
Fitoterapia. 2016 Jan;108:93-7. doi: 10.1016/j.fitote.2015.11.020. Epub 2015 Nov 26.
Chemical examination of the ethanol extract of rhizomes of Iris tectorum led to the isolation and characterization of three new lignans, (7R,7'R,8S,8'S)-5'-methoxy-neo-olivil (1a), (7S,7'S,8R,8'R) -5'-methoxy-neo-olivil (1b), (7S,7'R,8S,8'S)-neo-olivil (2a), (7R,7'S,8R,8'R)-neo-olivil (2b), (7R,7'R,8S,8'S,7''S,8''S)-threo-neo-olivil-4'-O-8-guaiacylglycerol ether (3), together with six known ones (4-9). Among them, compounds 1 and 2 were found to be racemic mixtures, respectively, which were verified by chiral HPLC analysis, compound 3 was a new sesquineolignan. The structures were elucidated on the basis of extensive spectroscopic analysis. To our knowledge, this is the first report of lignan constituents isolated from I. tectorum. All compounds were evaluated for their cytotoxicity against five human tumor cell lines and none of them displayed significant toxicity in tested cell lines at a concentration of 10 μM.
对鸢尾根茎乙醇提取物进行化学分析，分离并鉴定出三种新的木脂素，即(7R,7'R,8S,8'S)-5'-甲氧基新橄榄脂素(1a)、(7S,7'S,8R,8'R)-5'-甲氧基新橄榄脂素(1b)、(7S,7'R,8S,8'S)-新橄榄脂素(2a)、(7R,7'S,8R,8'R)-新橄榄脂素(2b)、(7R,7'R,8S,8'S,7''S,8''S)-苏式新橄榄脂素-4'-O-8-愈创木基甘油醚(3)，以及六种已知化合物(4 - 9)。其中，化合物1和2分别为外消旋混合物，经手性高效液相色谱分析验证，化合物3是一种新的倍半木脂素。通过广泛的光谱分析阐明了其结构。据我们所知，这是首次从鸢尾中分离出木脂素成分的报道。评估了所有化合物对五种人类肿瘤细胞系的细胞毒性，在10 μM浓度下，它们在测试的细胞系中均未显示出显著毒性。
