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Frameshift mutations of ATBF1, WNT9A, CYLD and PARK2 in gastric and colorectal carcinomas with high microsatellite instability.

作者信息

An Chang Hyeok, Kim Sung Soo, Kang Mi Ran, Kim Yoo Ri, Kim Ho Shik, Yoo Nam Jin, Lee Sug Hyung

出版信息

Pathology. 2010;42(6):583-5. doi: 10.3109/00313025.2010.508735.

DOI:10.3109/00313025.2010.508735
PMID:20854080
Abstract
摘要

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Frameshift mutations of ATBF1, WNT9A, CYLD and PARK2 in gastric and colorectal carcinomas with high microsatellite instability.具有高微卫星不稳定性的胃癌和结直肠癌中ATBF1、WNT9A、CYLD和PARK2的移码突变
Pathology. 2010;42(6):583-5. doi: 10.3109/00313025.2010.508735.
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Frameshift mutations of tumor suppressor gene EP300 in gastric and colorectal cancers with high microsatellite instability.肿瘤抑制基因 EP300 在具有高度微卫星不稳定性的胃癌和结直肠癌中的移码突变。
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Frameshift mutations of autophagy-related genes ATG2B, ATG5, ATG9B and ATG12 in gastric and colorectal cancers with microsatellite instability.具有微卫星不稳定性的胃癌和结直肠癌中自噬相关基因ATG2B、ATG5、ATG9B和ATG12的移码突变
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Frameshift mutations of a chromatin-remodeling gene SMARCC2 in gastric and colorectal cancers with microsatellite instability.在具有微卫星不稳定性的胃癌和结直肠癌中，染色质重塑基因SMARCC2的移码突变
APMIS. 2013 Feb;121(2):168-9. doi: 10.1111/j.1600-0463.2012.02953.x. Epub 2012 Jul 27.

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Loss of CYLD expression unleashes Wnt signaling in multiple myeloma and is associated with aggressive disease.
CYLD 表达缺失会引发多发性骨髓瘤中的 Wnt 信号通路，并与侵袭性疾病相关。
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Epidermal CYLD inactivation sensitizes mice to the development of sebaceous and basaloid skin tumors.表皮CYLD失活使小鼠对皮脂腺和基底样皮肤肿瘤的发生敏感。
JCI Insight. 2016 Jul 21;1(11). doi: 10.1172/jci.insight.86548.
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