Prehn Richmond T, Prehn Liisa M
Dept of Pathology, University of Washington, 5433 South Hudson St, Seattle, WA 98118, USA.
Theor Biol Med Model. 2010 Sep 20;7:38. doi: 10.1186/1742-4682-7-38.
Allophenic mice, supposedly containing almost equal numbers of cells derived from embryos of mouse strains C57Bl and FVB, were shown in a recent paper to grow the B16 melanoma, a long transplanted tumor of C57Bl origin, much better than did mice of either the parental C57Bl strain or the C57Bl x FVB F1 hybrid. Mice containing smaller proportions of C57Bl cells rejected the tumor. A reconsideration of these suprising data, in light of the current literature, suggests that the better growth of the tumor in the 50-50% allophenics than in the C57Bl parental strain was almost certainly caused by the tumor stimulation engendered by a weak anti-C57Bl immune reaction in the overtly healthy allophenic mice.
异表型小鼠被认为含有几乎等量的源自C57Bl和FVB小鼠品系胚胎的细胞，近期一篇论文显示，它们生长B16黑色素瘤（一种长期移植的源自C57Bl的肿瘤）的情况比亲代C57Bl品系或C57Bl×FVB F1杂种小鼠都要好得多。含有较小比例C57Bl细胞的小鼠会排斥该肿瘤。根据当前文献重新审视这些惊人数据表明，在50-50%异表型小鼠中肿瘤生长情况优于C57Bl亲代品系，几乎可以肯定是由表面健康的异表型小鼠中微弱的抗C57Bl免疫反应所产生的肿瘤刺激导致的。
