Ohsawa N
First Department of Internal Medicine, Osaka Medical College, Japan.
Hum Cell. 1990 Jun;3(2):91-8.
Polyamines are recognized as cell growth factors in relation to cell proliferation, differentiation, regeneration and malignant transformation. Polyamines play an important role in the growth of normal cells like vascular endothelial cells and also exert various effects on the proliferation and metastasis of malignant cells. The recent studies on the biosynthesis have clearly elucidated its mechanism at the gane levels, which reflects to the development of the inhibitors of the polyamine biosynthesis. One of the main purposes of the studies on the various polyamine synthesis inhibitors is for the development of new anti-cancer agents, based on the characteristics of the polyamine functions. The clinical effects of several inhibitors, however, have not been shown to be satisfactory and the reason is now the most important research subject in this field. The measurement of the polyamine contents in biological fluids including urine and blood has been shown to be useful as the tumor marker. The recent studies have indicated that the mechanism of increased secretion of urinary polyamines is due to the release from the degraded cancer cells. The results now stimulated the research which aims to elucidate the usefulness of the measurement of urinary polyamines as the parameters of the sensitivity to the anticancer drugs in patients with cancer.
多胺被认为是与细胞增殖、分化、再生和恶性转化相关的细胞生长因子。多胺在血管内皮细胞等正常细胞的生长中发挥重要作用，对恶性细胞的增殖和转移也有多种影响。最近关于生物合成的研究已经在基因水平上清楚地阐明了其机制，这反映在多胺生物合成抑制剂的开发上。基于多胺功能的特点，研究各种多胺合成抑制剂的主要目的之一是开发新的抗癌药物。然而，几种抑制剂的临床效果并不令人满意，其原因是目前该领域最重要的研究课题。已证明测量包括尿液和血液在内的生物体液中的多胺含量作为肿瘤标志物是有用的。最近的研究表明，尿多胺分泌增加的机制是由于降解的癌细胞释放所致。这些结果现在激发了旨在阐明测量尿多胺作为癌症患者对抗癌药物敏感性参数的有用性的研究。
