Division of Newborn Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA.
J Pediatr. 2011 Feb;158(2):227-33. doi: 10.1016/j.jpeds.2010.07.052. Epub 2010 Sep 19.
To determine the extent to which known prenatal and perinatal predictors of childhood obesity also predict weight gain in early infancy.
We studied 690 infants participating in the prospective cohort Project Viva. We measured length and weight at birth and at 6 months. Using multivariable linear regression, we examined relationships of selected maternal and infant factors with change in weight-for-length z-score (WFL-z) from 0 to 6 months.
Mean (standard deviation) change in WFL-z from 0 to 6 months was 0.23 (1.11), which translates to 4500 grams gained from birth to 6 months of life in an infant with average birth weight and length. After adjustment for confounding variables and birth weight-for-gestational age z-score (-0.28 [95% confidence interval, -0.37, -0.19] per unit), cord blood leptin (-0.40 [95%confidence interval, -0.61, -0.19] per 10 ng/mL), and gestational diabetes -0.50 [95%confidence interval, -0.88, -0.11] versus normal glucose tolerance)were each associated with slower gain in WFL-z from 0 to 6 months.
Higher neonatal leptin and gestational diabetes predicted slower weight gain in the first 6 months of life. The hormonal milieu of the intrauterine environment may determine growth patterns in early infancy and thus later obesity.
确定已知的产前和围产期儿童肥胖预测因素在多大程度上也可预测婴儿早期的体重增加。
我们研究了参加前瞻性队列研究项目 Viva 的 690 名婴儿。我们在出生时和 6 个月时测量了长度和体重。使用多变量线性回归，我们检查了选定的产妇和婴儿因素与从 0 到 6 个月体重长度 Z 分数（WFL-z）变化的关系。
从 0 到 6 个月 WFL-z 的平均（标准差）变化为 0.23（1.11），这意味着在平均出生体重和长度的婴儿中，从出生到 6 个月的生命中体重增加了 4500 克。在校正混杂变量和出生体重与胎龄 Z 分数（每单位-0.28 [95%置信区间，-0.37，-0.19]）、脐带血瘦素（每 10ng/mL-0.40 [95%置信区间，-0.61，-0.19]）和妊娠期糖尿病（与正常葡萄糖耐量相比-0.50 [95%置信区间，-0.88，-0.11]）后，WFL-z 从 0 到 6 个月的增长速度较慢。
较高的新生儿瘦素和妊娠期糖尿病预测了生命前 6 个月体重增加较慢。宫内环境的激素环境可能决定婴儿早期的生长模式，从而影响后期肥胖。
