[健康志愿者唾液与血清中奥硝唑浓度的相关性]
[Correlation of ornidazole concentration in saliva and serum of healthy volunteers].
作者信息
Jiang Yi, Liu Hong-chen, Wu Xia, Feng Chun-zhen, Chang Ping, Zhang Xian-hua
机构信息
Department of Stomatology, General Hospital of PLA, Beijing 100853, China.
出版信息
Nan Fang Yi Ke Da Xue Xue Bao. 2010 Sep;30(9):2108-10.
OBJECTIVE
To investigate the distribution of ornidazole in the salivary and serum of healthy adults and explore the feasibility of monitoring serum drug concentration with salivary.
METHODS
Six volunteers received a single dose of 0.6 g ornidazole via intravenous infusion. The concentrations of ornidazole in the saliva and serum were assayed by high-performance liquid chomatography, and the correlation of the drug concentrations in saliva to that in serum was analyzed.
RESULTS
The concentration of ornidazole in the saliva was strongly associated with that in the serum (r = 0.825-0.969), and the ratio of saliva-to-serum concentration (S/P) of ornidazole was 0.99 ± 0.13.
CONCLUSION
Detection of saliva ornidazole concentration is feasible for monitoring the therapeutic concentration of ornidazole.
目的
研究奥硝唑在健康成年人唾液和血清中的分布情况，并探讨通过唾液监测血清药物浓度的可行性。
方法
6名志愿者静脉滴注单剂量0.6 g奥硝唑。采用高效液相色谱法测定唾液和血清中奥硝唑的浓度，并分析唾液中药物浓度与血清中药物浓度的相关性。
结果
唾液中奥硝唑浓度与血清中奥硝唑浓度密切相关（r = 0.825 - 0.969），奥硝唑的唾液与血清浓度比（S/P）为0.99 ± 0.13。
结论
检测唾液中奥硝唑浓度对于监测奥硝唑的治疗浓度是可行的。
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