Correa-Rotter R, Saldivar S, Soto L E, Ponce de Leon S, Ojeda F, Ruiz-Palacios G, Pena J C
Department of Nephrology, Instituto Nacional de la Nutricion Salvador Zubiran, Mexico City, Mexico.
Perit Dial Int. 1990;10(1):67-9.
We investigated the presence of HIV antigen in dialysis fluid of patients with end-stage renal disease (ESRD) undergoing continuous ambulatory peritoneal dialysis (CAPD), previously known to be infected with this virus. Sixteen adult patients and 6 adult volunteers were included in the study in 4 groups as follows: Group A: 3 patients on CAPD, previously known to be positive for serum HIV antibodies; Group B: 7 patients on CAPD, serum HIV negative; Group C: 6 AIDS patients without renal disease; and Group D: 6 healthy volunteers. Of the 3 patients of Group A, the HIV-1 Ag was positive in dialysis fluid in only 2. In 1, serum Ab and Ag were present, while in the others only serum Ab was detected. The samples from Group B were all negative for the viral antigen in dialysis fluid. We conclude that dialysis fluid of HIV-infected patients may contain the Ag and is therefore potentially infective. The presence of the HIV antigen was not constant, and was not related to antigenemia. It is possible that the presence of the Ag depends on local factors that influence viral replication or to alterations in the permeability of the peritoneal membrane. We discuss other possible factors that could influence the presence of viral Ag in peritoneal dialysis fluid.
我们对已知感染人类免疫缺陷病毒（HIV）的终末期肾病（ESRD）患者在进行持续性非卧床腹膜透析（CAPD）时透析液中HIV抗原的存在情况进行了研究。本研究纳入了16例成年患者和6名成年志愿者，分为以下4组：A组：3例进行CAPD的患者，已知血清HIV抗体呈阳性；B组：7例进行CAPD的患者，血清HIV阴性；C组：6例无肾脏疾病的艾滋病患者；D组：6名健康志愿者。A组的3例患者中，仅2例透析液中的HIV-1抗原呈阳性。1例患者血清中同时存在抗体和抗原，而其他患者仅检测到血清抗体。B组患者的透析液病毒抗原检测均为阴性。我们得出结论，HIV感染患者的透析液可能含有抗原，因此具有潜在传染性。HIV抗原的存在并不恒定，且与抗原血症无关。抗原的存在可能取决于影响病毒复制的局部因素或腹膜通透性的改变。我们讨论了其他可能影响腹膜透析液中病毒抗原存在的因素。
