Faculdade de Medicina de Botucatu, Botucatu, SP, Brasil.
Arq Bras Cardiol. 2010 Oct;95(5):635-9. doi: 10.1590/s0066-782x2010005000130. Epub 2010 Sep 24.
The relevance of the remodeling pattern in the model of infarcted rats is not known.
To analyze the presence of different patterns of remodeling in this model and its functional implications.
Infarcted rats (n=47) have been divided according to the geometry pattern, analyzed by echocardiogram: normal (normal mass index and normal relative thickness), concentric remodeling (normal mass index and increased relative thickness), concentric hypertrophy (increased mass index and increased relative thickness) and eccentric hypertrophy (increased mass index and normal relative thickness). Data are median and interquartile range.
Infarcted rats showed only two of the four geometric patterns: normal pattern (15%) and eccentric hypertrophy - EH (85%). Groups of normal pattern and EH showed no differences in the values of fractional area change (Normal = 32.1 - 28.8 to 50.7; EH = 31.3 - 26.5 to 36.7; p = 0.343). Out of the infarcted animals, 34 (74%) had systolic dysfunction, detected by fractional area change. Considering these two geometry patterns, 77% of animals with eccentric hypertrophy and 57% with normal geometry presented systolic dysfunction (p=0.355). The relative wall thickness, the geometric patterns and the body mass index were not predictors of ventricular dysfunction (p> 0.05). On the other hand, infarct size was a predictive factor for ventricular dysfunction in univariate analysis (p<0.001) and multivariate analysis (p = 0.004).
Rats that underwent coronary occlusion showed two different patterns of remodeling, which do not constitute a predictor of ventricular dysfunction.
梗死大鼠模型中重构模式的相关性尚不清楚。
分析该模型中不同重构模式的存在及其功能意义。
根据超声心动图分析将梗死大鼠（n=47）分为以下几何模式：正常（正常质量指数和正常相对厚度）、向心性重构（正常质量指数和相对厚度增加）、向心性肥厚（质量指数增加和相对厚度增加）和偏心性肥厚（质量指数增加和相对厚度正常）。数据为中位数和四分位距。
梗死大鼠仅显示了四种几何模式中的两种：正常模式（15%）和偏心性肥厚-EH（85%）。正常模式和 EH 组在分数面积变化值上没有差异（正常=32.1-28.8 至 50.7；EH=31.3-26.5 至 36.7；p=0.343）。在梗死动物中，34 只（74%）存在收缩功能障碍，通过分数面积变化检测到。考虑到这两种几何模式，77%的偏心性肥厚动物和 57%的正常几何动物存在收缩功能障碍（p=0.355）。相对壁厚度、几何模式和体重指数不是心室功能障碍的预测因素（p>0.05）。另一方面，在单因素分析（p<0.001）和多因素分析（p=0.004）中，梗死面积是心室功能障碍的预测因素。
接受冠状动脉闭塞的大鼠显示出两种不同的重构模式，这不能预测心室功能障碍。
