Universidade Federal de Ouro Preto, Belo Horizonte, MG.
Arq Bras Cardiol. 2010 Aug;95(2):272-8. doi: 10.1590/s0066-782x2010001200020.
Many researches have been conducted in experimental models in order to study the development of atherosclerosis from hyperlipidemia-inducing diets. Since rabbits are very sensitive to cholesterol-rich diets and accumulate large amounts of cholesterol in their plasma, their use as experimental models to evaluate the development of atherosclerosis is highly relevant and brings information on factors that contribute to the progression and regression of this condition that can be applied to humans. As such, this review includes studies on the atherogenic function of cholesterol based on rabbits as the experimental model, since they have become the most largely used experimental model of atherosclerosis.
许多研究已经在实验模型中进行，以研究高脂血症诱导饮食引起的动脉粥样硬化的发展。由于兔子对富含胆固醇的饮食非常敏感，并在其血浆中积累大量胆固醇，因此它们被用作评估动脉粥样硬化发展的实验模型非常相关，并提供了有助于该疾病进展和消退的因素的信息，这些信息可应用于人类。因此，本综述包括基于兔子作为实验模型的胆固醇致动脉粥样硬化功能的研究，因为它们已成为最广泛使用的动脉粥样硬化实验模型。
