Arce V, Cella S G, Loche S, Ghigo E, Devesa J, Müller E E
Department of Pharmacology, Chemotherapy and Toxicology, University of Milan, Italy.
Brain Res. 1990 Dec 24;537(1-2):359-62. doi: 10.1016/0006-8993(90)90386-p.
The effect of acute administration of growth hormone-releasing hormone (GHRH), clonidine (CLO), an alleged GHRH releaser, or GHRH and clonidine given simultaneously was studied in young and old dogs. Simultaneous administration of CLO induced in young dogs an additive effect on GH release and potentiated in old dogs the GHRH-induced GH release, with the GH response being clearly higher than the sum of the GH responses to GHRH or CLO alone. These data suggest that CLO promotes GH release in the dog also by inhibition of somatostatin release.
研究了急性给予生长激素释放激素（GHRH）、可乐定（CLO）（一种所谓的GHRH释放剂）或同时给予GHRH和可乐定对年轻和老年犬的影响。在年轻犬中，同时给予可乐定对生长激素（GH）释放产生相加效应，而在老年犬中则增强了GHRH诱导的GH释放，其GH反应明显高于单独给予GHRH或可乐定的GH反应之和。这些数据表明，可乐定在犬中也通过抑制生长抑素释放来促进GH释放。
