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High expression levels of the mammalian target of rapamycin inhibitor DEPTOR are predictive of response to thalidomide in myeloma.

作者信息

Boyd Kevin D, Walker Brian A, Wardell Christopher P, Ross Fiona M, Gregory Walter M, Davies Faith E, Morgan Gareth J

出版信息

Leuk Lymphoma. 2010 Nov;51(11):2126-9. doi: 10.3109/10428194.2010.509893. Epub 2010 Sep 21.

DOI:10.3109/10428194.2010.509893
PMID:20858096
Abstract
摘要

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Int J Mol Med. 2021 Feb;47(2):643-658. doi: 10.3892/ijmm.2020.4831. Epub 2020 Dec 24.
2
Prognostic and clinicopathological significance of DEPTOR expression in cancer patients: a meta-analysis.DEPTOR表达在癌症患者中的预后及临床病理意义:一项荟萃分析
Onco Targets Ther. 2018 Aug 22;11:5083-5092. doi: 10.2147/OTT.S167355. eCollection 2018.
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HMGB1 knockdown increases MM cell vulnerability by regulating autophagy and DNA damage repair.
HMGB1 敲低通过调节自噬和 DNA 损伤修复增加 MM 细胞的易损性。
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Intravesical Thalidomide boosts bacillus Calmette-Guérin (BCG) in non-muscle invasive bladder cancer treatment.经尿道沙利度胺增强卡介苗在非肌肉浸润性膀胱癌治疗中的作用。
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DEPTOR maintains plasma cell differentiation and favorably affects prognosis in multiple myeloma.DEPTOR维持浆细胞分化并对多发性骨髓瘤的预后产生有利影响。
J Hematol Oncol. 2017 Apr 18;10(1):92. doi: 10.1186/s13045-017-0461-8.
6
Deptor: not only a mTOR inhibitor.Deptor:不仅仅是一种mTOR抑制剂。
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Small molecule therapeutics targeting F-box proteins in cancer.针对癌症中F-box蛋白的小分子疗法。
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DEPTOR is linked to a TORC1-p21 survival proliferation pathway in multiple myeloma cells.DEPTOR与多发性骨髓瘤细胞中的TORC1-p21生存增殖途径相关联。
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