Meyerson Howard J
Department of Pathology and Ireland Cancer Center of Case Western Reserve University/University Hospitals Case Medical Center, Cleveland, Ohio 44106 , USA.
Lab Hematol. 2010 Sep;16(3):32-52. doi: 10.1532/LH96.10001.
The flow cytometric analysis of T-cell malignancies is difficult due to the heterogeneity of T-cells and the lack of convenient methods to detect T-cell clonality. Neoplastic T-cells are most often detected by their altered level of surface antigen expression, and detection requires an extensive knowledge of the phenotype of normal T-lymphocytes. This review focuses on the methods to distinguish malignant T-cells from their normal counterparts and the phenotypic features of the T-cell lymphoproliferative disorders.
由于T细胞的异质性以及缺乏检测T细胞克隆性的便捷方法，T细胞恶性肿瘤的流式细胞术分析颇具难度。肿瘤性T细胞最常通过其表面抗原表达水平的改变来检测，而这种检测需要对正常T淋巴细胞的表型有广泛的了解。本文综述着重于区分恶性T细胞与其正常对应细胞的方法以及T细胞淋巴增殖性疾病的表型特征。
