5-氟尿嘧啶衍生物。XX。5'-O-不饱和酰基-5-氟尿苷的合成与抗肿瘤活性。
5-Fluorouracil derivatives. XX. Synthesis and antitumor activity of 5'-O-unsaturated acyl-5-fluorouridines.
作者信息
Ozaki S, Akiyama T, Morita T, Kumegawa M, Nagase T, Uehara N, Hoshi A
机构信息
Department of Resources Chemistry, Faculty of Engineering, Ehime University, Matsuyama, Japan.
出版信息
Chem Pharm Bull (Tokyo). 1990 Nov;38(11):3164-6. doi: 10.1248/cpb.38.3164.
PMID:2085902
Abstract
Various kinds of 5'-O-unsaturated acyl 5-fluorouridines were synthesized to obtain 5-fluorouridine derivatives with low toxicity and high antitumor activity. Antitumor activity of the compounds against L-1210 leukemia in mice was examined, and the 5'-O-4-pentenoyl derivative showed the highest antitumor activity.
摘要
合成了各种5'-O-不饱和酰基5-氟尿苷，以获得低毒且具有高抗肿瘤活性的5-氟尿苷衍生物。检测了这些化合物对小鼠L-1210白血病的抗肿瘤活性，其中5'-O-4-戊烯酰基衍生物表现出最高的抗肿瘤活性。
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