Mochizuki A, Yamanouchi H, Kitamura K, Nagura H, Yoshikawa H
Department of Neurology, Faculty of Medicine, Tsukuba University.
Rinsho Shinkeigaku. 1990 Nov;30(11):1278-82.
A case with non-paralytic pontine exotropia (NPPE) due to brainstem infarction is reported. A 77-year-old hypertensive man suddenly developed dizziness, double vision, dysarthria, and right ataxic hemiparesis. Oculomotor findings on admission consisted of: (1) full right exotropia in the primary position; (2) complete adductive paralysis of the left eye with slight preservation of convergence; (3) tonic deviation of the right eye to the full abducting position with right-beating nystagmus after an immediate forward gaze. The leftward saccades showed multiple saccades with slow velocity on electronystagmography (ENG). The right exotropia disappeared and the slight adductive paresis of the left eye remained with right monocular nystagmus seven weeks after the onset. Magnetic resonance imaging (MRI), which was performed nine weeks after the onset, disclosed a small lesion with high intensity involving the left medial longitudinal fasciculus (MLF) on T2-weighted spin echo image. The leftward saccades showed multiple saccades with normal velocity eleven weeks after the onset. The hypofunction of unilateral PPRF with ipsilateral MLF lesion probably causes the contralateral NPPE.
报告了一例因脑干梗死导致的非麻痹性脑桥外斜视(NPPE)病例。一名77岁的高血压男性突然出现头晕、复视、构音障碍和右侧共济失调性偏瘫。入院时的动眼神经检查结果包括:(1)第一眼位时右眼完全外斜视;(2)左眼完全内收麻痹,集合功能稍有保留;(3)向前直视后,右眼强直性偏斜至完全外展位,并伴有右眼跳动性眼球震颤。眼震电图(ENG)显示向左扫视时出现多个速度缓慢的扫视。发病7周后,右眼外斜视消失,左眼轻微内收麻痹伴右眼单眼眼球震颤。发病9周后进行的磁共振成像(MRI)显示,在T2加权自旋回波图像上,左侧内侧纵束(MLF)有一个小的高强度病变。发病11周后,向左扫视显示多个速度正常的扫视。单侧脑桥旁正中网状结构(PPRF)功能减退伴同侧MLF病变可能导致对侧NPPE。