Vascular Biology Center, Medical College of Georgia, Augusta, Georgia, USA.
Pharm Res. 2011 Feb;28(2):413-6. doi: 10.1007/s11095-010-0283-7. Epub 2010 Sep 22.
Inflammatory disorders are characterized by the influx of immune cells into the vascular wall of veins and/or arteries in response to stimuli such as oxidized-LDL and various pathogens. These factors stimulate the local production of pro-inflammatory cytokines by macrophages and other cells that promote various inflammatory diseases such as atherosclerosis, Crohn's, Alzheimer's and diabetes. Numerous cytokines play a significant role in this process, though tumor necrosis factor (TNF) and various interleukins are thought to be among the most important regulators. These proinflammatory cytokines promote the above-described diseases by inducing endothelial cell dysfunction. In this brief commentary we will discuss some of the latest advances and discoveries in the treatment of these inflammatory diseases, making use of alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) agonists.
炎症性疾病的特征是免疫细胞响应氧化型 LDL 和各种病原体等刺激物涌入静脉和/或动脉的血管壁。这些因素刺激巨噬细胞和其他细胞局部产生促炎细胞因子，从而促进动脉粥样硬化、克罗恩病、阿尔茨海默病和糖尿病等各种炎症性疾病的发生。许多细胞因子在这个过程中发挥着重要作用，尽管肿瘤坏死因子 (TNF) 和各种白细胞介素被认为是最重要的调节因子之一。这些促炎细胞因子通过诱导内皮细胞功能障碍来促进上述疾病的发生。在这篇简要的评论中，我们将讨论利用α7 烟碱型乙酰胆碱受体 (α7 nAChR) 激动剂治疗这些炎症性疾病的最新进展和发现。
