Zhang J, Sun J P, He J B
Department of Cardiology, PLA General Hospital.
Zhonghua Nei Ke Za Zhi. 1990 Nov;29(11):653-5, 701.
To verify whether ginsenosides will attenuate the myocardial ischemia and reperfusion injury, the left anterior descending coronary artery (LAD) was snared for 2 hours in 23 dogs and then the ischemic myocardium was reperfused. 45 minutes after ischemia, the animals were randomly divided into a ginsenosides group (n = 11, receiving a slow IV bolus of ginsenosides 10 mg/kg and then a continuous infusion of 80 micrograms/kg/min) and a saline solution group (n = 12 receiving equal amount of glucose in saline). The treatment was started 45 minutes after coronary occlusion and stopped one hour after reperfusion. 24 hours later, the dogs were killed and the extent of myocardial necrosis was determined histologically. The LVEDP, arterial pressure and heart rate were markedly lower in the ginsenosides group. Electrocardiographic findings of myocardial ischemia were significantly improved in the ginsenosides group. 8 controls developed malignant arrhythmia after reperfusion, but none in ginsenosides group. The myocardial ultrastructure can be protected by ginsenosides during the period of ischemia and reperfusion. The infarct size in saline group was 22.7 +/- 3.2% while in the ginsenosides group it was 5.2 +/- 1.3% (P less than 0.05). These results show that ginsenosides can protect the ischemic myocardium and reperfusion injury of myocardium.
为验证人参皂苷是否会减轻心肌缺血及再灌注损伤，在23只犬中结扎左冠状动脉前降支（LAD）2小时，然后对缺血心肌进行再灌注。缺血45分钟后，将动物随机分为人参皂苷组（n = 11，静脉缓慢推注人参皂苷10 mg/kg，然后以80微克/千克/分钟持续输注）和生理盐水组（n = 12，接受等量的葡萄糖生理盐水）。治疗在冠状动脉闭塞45分钟后开始，再灌注1小时后停止。24小时后，处死犬，组织学测定心肌坏死程度。人参皂苷组的左室舒张末压、动脉压和心率明显较低。人参皂苷组心肌缺血的心电图表现明显改善。8只对照组在再灌注后出现恶性心律失常，但人参皂苷组无一例发生。人参皂苷可在缺血和再灌注期间保护心肌超微结构。生理盐水组梗死面积为22.7±3.2%，而人参皂苷组为5.2±1.3%（P<0.05）。这些结果表明，人参皂苷可保护缺血心肌及心肌再灌注损伤。
