Fang D C, Liu W W
Department of Gastroenterology, Southwest Hospital, Third Military Medical College, Chongqing.
Zhonghua Nei Ke Za Zhi. 1990 Aug;29(8):465-8, 509-10.
The expression of 9 tumor-associated antigens (MG7-, MGd1-, MC3-corresponding antigens and CEA, P21ras, sialoglycoprotein, CA19-9-like, sialo-Tn and Lea-like antigens) were investigated on biopsy specimens with different types of intestinal metaplasia (types I, II and III) taken from 112 patients with benign gastric conditions. The incidences of positive staining for all antigens but P21ras in type III intestinal metaplasia were significantly higher than those in types I and II (P less than 0.05-0.001). These 112 patients with intestinal metaplasia were clinico-endoscopic followed-up for 15-70 months. Five of them were found to develop gastric carcinoma within 25-60 months with a cancer detection rate of 4.5%. All the five malignancies were detected in patients with type III (16.1%), none was found in those with types I and II, these differences were significant (P less than 0.05-0.01). Our results indicate that type III intestinal metaplasia has a higher potentiality to evolve to malignancy and that MG7, MGd1, MC3, CEA, CA19-9-like and sialo-Tn antigens are valuable tumor markers in defining the high-risk group of gastric cancer.
对112例患有良性胃部疾病患者的活检标本进行研究，这些标本具有不同类型的肠化生（I型、II型和III型），检测9种肿瘤相关抗原（MG7、MGd1、MC3相应抗原以及癌胚抗原、P21ras、唾液糖蛋白、CA19-9样抗原、唾液酸-Tn和Lea样抗原）的表达情况。III型肠化生中除P21ras外所有抗原的阳性染色发生率均显著高于I型和II型（P＜0.05 - 0.001）。对这112例肠化生患者进行了15 - 70个月的临床内镜随访。其中5例在25 - 60个月内发生了胃癌，癌症检出率为4.5%。所有5例恶性肿瘤均在III型患者中检出（16.1%），I型和II型患者中未发现，这些差异具有显著性（P＜0.05 - 0.01）。我们的结果表明，III型肠化生具有更高的恶变潜能，并且MG7、MGd1、MC3、癌胚抗原、CA19-9样抗原和唾液酸-Tn抗原是界定胃癌高危人群的有价值的肿瘤标志物。
