L-精氨酸/不对称二甲基精氨酸、同型半胱氨酸、叶酸、维生素B水平与冠状动脉扩张之间的关系

Relationship between L-arginine/asymmetric dimethylarginine, homocysteine, folic acid, vitamin B levels, and coronary artery ectasia.

作者信息

Koc Fatih, Ardic Idris, Erdem Sami, Kalay Nihat, Ozbek Kerem, Yarlioglues Mikail, Ceyhan Koksal, Celik Atac, Kadi Hasan, Taner Alpaslan, Sahin Semsettin, Onalan Orhan, Kaya Mehmet Gungor

机构信息

Department of Cardiology, Gaziosmanpasa University School of Medicine, Tokat, Turkey.

出版信息

Coron Artery Dis. 2010 Dec;21(8):445-9. doi: 10.1097/MCA.0b013e32833fd22b.

DOI:10.1097/MCA.0b013e32833fd22b

PMID:20861735

Abstract

BACKGROUND

Coronary artery ectasia (CAE) is characterized by an abnormal dilatation of the coronary arteries. The ratio of L-arginine/asymmetric dimethylarginine (ADMA) and homocysteine are important factors for endothelial function. In this study, we investigate the ratio of L-arginine/ADMA, homocysteine, and folic acid/vitamin B levels in patients with CAE.

METHODS

Forty patients diagnosed with CAE using coronary angiography were included in the study (24 male; mean age, 56 ± 11 years). The control group consisted of 30 patients who had normal coronary arteries as determined by coronary angiography (11 male; mean age, 54 ± 8 years). The ratio of L-arginine/ADMA and plasma homocysteine was measured using high-performance liquid chromatography.

RESULTS

The L-arginine/ADMA ratio and L-arginine levels were significantly lower in the CAE group compared with the control group (110 ± 27 vs. 149 ± 77, P=0.02 and 157 ± 32 μmol/l vs. 187 ± 59 μmol/l, P=0.02, respectively). Plasma ADMA levels were similar in the two groups. Patients with CAE had higher plasma homocysteine levels (P=0.01). Plasma folic acid, vitamin B6, and vitamin B12 levels were similar between the two groups.

CONCLUSION

This study shows that patients with CAE have a lower L-arginine/ADMA ratio and higher plasma homocysteine levels. These results show a potential relationship between endothelial dysfunction and CAE.

摘要

背景

冠状动脉扩张（CAE）的特征是冠状动脉异常扩张。L-精氨酸/不对称二甲基精氨酸（ADMA）比值和同型半胱氨酸是影响内皮功能的重要因素。在本研究中，我们调查了CAE患者中L-精氨酸/ADMA比值、同型半胱氨酸以及叶酸/维生素B水平。

方法

本研究纳入了40例经冠状动脉造影诊断为CAE的患者（男性24例；平均年龄56±11岁）。对照组由30例经冠状动脉造影显示冠状动脉正常的患者组成（男性11例；平均年龄54±8岁）。采用高效液相色谱法测定L-精氨酸/ADMA比值和血浆同型半胱氨酸水平。

结果

与对照组相比，CAE组的L-精氨酸/ADMA比值和L-精氨酸水平显著降低（分别为110±27 vs. 149±77，P=0.02；157±32 μmol/l vs. 187±59 μmol/l，P=0.02）。两组的血浆ADMA水平相似。CAE患者的血浆同型半胱氨酸水平较高（P=0.01）。两组间血浆叶酸、维生素B6和维生素B12水平相似。