Merali Z, Piggins H
School of Psychology, University of Ottawa, Ontario, Canada.
Eur J Pharmacol. 1990 Dec 4;191(3):281-93. doi: 10.1016/0014-2999(90)94160-y.
Central administration of bombesin elicits excessive grooming and locomotor activity in rats. This grooming activity is one characterised by vigorous scratching of the face, nape and body flanks. Pretreatment with the D1 receptor antagonist SCH 23390 inhibited the expression of bombesin-induced activity with grooming being more inhibited than locomotion. Blockade of D2 receptors with eticlopride significantly attenuated the behavioral responses to bombesin. When SCH 23390 and eticlopride were administered concurrently, it was apparent that D1 blockade had a greater effect on grooming and D2 blockade a larger effect on locomotion. Stimulation of D1 receptors by SKF 38393 elicited non-stereotyped locomotor activity and a form of grooming behavior characterised by vigorous washing of the face and ventral body surfaces. Co-administration of bombesin and SKF 38393 resulted in a form of grooming which resembled that elicited by SKF 38393 alone. The specific D2 agonist PPHT elicited a form of locomotion characterised by a downward oriented head posture and slow ambulatory activity around the cage perimeter. Co-administration of PPHT and bombesin resulted in a complete suppression of bombesin-induced behaviors and was largely indistinguishable from activity observed under PPHT alone conditions. These data implicate both D1 and D2 receptor based mechanisms in the modulation/mediation of the behavioral effects of bombesin. Part of the bombesin-induced behavioral effects may be explained by (indirect) activation of (a) dopamine system(s).
向大鼠中枢注射蛙皮素会引发过度梳理毛发和运动活动。这种梳理毛发的活动表现为用力抓挠脸部、颈部和身体两侧。用D1受体拮抗剂SCH 23390预处理可抑制蛙皮素诱导的活动表达，其中梳理毛发行为比运动行为受到的抑制更明显。用依替必利阻断D2受体可显著减弱对蛙皮素的行为反应。当同时给予SCH 23390和依替必利时，显然D1受体阻断对梳理毛发行为影响更大，而D2受体阻断对运动行为影响更大。SKF 38393刺激D1受体可引发非刻板运动活动以及一种以用力清洗脸部和腹部身体表面为特征的梳理毛发行为。同时给予蛙皮素和SKF 38393会产生一种类似于单独给予SKF 38393时引发的梳理毛发行为。特异性D2激动剂PPHT引发一种以头部向下姿势和在笼子周边缓慢走动为特征的运动形式。同时给予PPHT和蛙皮素会完全抑制蛙皮素诱导的行为，并且与单独给予PPHT时观察到的活动在很大程度上难以区分。这些数据表明，D1和D2受体介导的机制都参与了蛙皮素行为效应的调节/介导。蛙皮素诱导的部分行为效应可能是由（一个或多个）多巴胺系统的（间接）激活所解释的。
