Amarapurkar D N, Juneja M P, Patel N D, Amarapurkar A D, Amarapurkar P D
Department of Gastroenterology & Hepatology, Bombay Hospital Medical Research centre, Mumbai.
Trop Gastroenterol. 2010 Apr-Jun;31(2):101-4.
Gastrointestinal tract is the commonest site for neuroendocrine tumors. Appendix, ileum and rectum were considered to be common sites for these tumors. However, there has been change in pattern of gastrointestinal neuroendocrine tumors over last few years. There is limited data available on epidemiology and patterns of these tumors in India.
Analysis of 74 patients with gastrointestinal and pancreatic neuroendocrine tumors over a period of 7 years at a single center in Mumbai, India was done. Clinical details, surgical outcome with follow up and treatment were reviewed. All these patients were analyzed with special emphasis on the site of the tumor.
The results showed a male preponderance (ratio of 2.5:1) with a mean age of 53.01 +/- 15.13 years. Of the 74 tumors, the commonest site was found to be stomach 22 (30.2%), followed by pancreas 17 (23.3%) and duodenum 14 (18.9%). Only 3 (4.1%) patients presented with carcinoid syndrome. The disease was localized in 46 (62.2%), regional spread was seen in 14 (18.9%) and distant spread in 14 (18.9%). Majority of gastric and duodenal tumors had localized disease while pancreatic NETs led to most of the cases with distant disease.
This analysis showed that gastrointestinal and pancreatic neuroendocrine tumors are not rare. Pattern of these tumors has definitely changed over last few years. Stomach was found to be commonest site for gastrointestinal neuroendocrine tumors followed by pancreas and duodenum.
胃肠道是神经内分泌肿瘤最常见的发生部位。阑尾、回肠和直肠被认为是这些肿瘤的常见发病部位。然而，在过去几年中，胃肠道神经内分泌肿瘤的发病模式已经发生了变化。关于印度这些肿瘤的流行病学和发病模式的数据有限。
对印度孟买一个单一中心7年间的74例胃肠道和胰腺神经内分泌肿瘤患者进行了分析。回顾了临床细节、手术结果及随访和治疗情况。对所有这些患者进行分析时特别强调了肿瘤的发病部位。
结果显示男性占优势（比例为2.5:1），平均年龄为53.01±15.13岁。在74例肿瘤中，最常见的发病部位是胃，共22例（30.2%），其次是胰腺17例（23.3%）和十二指肠14例（18.9%）。只有3例（4.1%）患者出现类癌综合征。疾病局限于46例（62.2%），区域扩散见于14例（18.9%），远处扩散见于14例（18.9%）。大多数胃和十二指肠肿瘤为局限性疾病，而胰腺神经内分泌肿瘤导致大多数远处转移病例。
该分析表明胃肠道和胰腺神经内分泌肿瘤并不罕见。在过去几年中，这些肿瘤的发病模式肯定发生了变化。胃被发现是胃肠道神经内分泌肿瘤最常见的发病部位，其次是胰腺和十二指肠。
