Manchester Centre for Integrative Systems Biology, Manchester Interdisciplinary Biocentre, University of Manchester, 131 Princess Street, Manchester M1 7DN, UK.
Biochem Soc Trans. 2010 Oct;38(5):1189-96. doi: 10.1042/BST0381189.
Biology and medicine have become 'big science', even though we may not always like this: genomics and the subsequent analysis of what the genomes encode has shown that interesting living organisms require many more than 300 gene products to interact. We once thought that somewhere in this jungle of interacting macromolecules was hidden the molecule that constitutes the secret of Life, and therewith of health and disease. Now we know that, somehow, the secret of Life is the jungle of interactions. Consequently, we need to find the Rosetta Stones, i.e. interpretations of this jungle of systems biology. We need to find, perhaps convoluted, paths of understanding and intervention. Systems biochemistry is a good place to start, as it has the foothold that what goes in must come out. In the present paper, we review two strategies, which look at control and regulation. We discuss the difference between control and regulation and prove a relationship between them.
生物学和医学已经成为“大科学”，尽管我们可能并不总是喜欢这样：基因组学以及随后对基因组编码内容的分析表明，有趣的生物需要超过 300 种基因产物来相互作用。我们曾经认为，在这个相互作用的大分子丛林中，隐藏着构成生命奥秘的分子，以及健康和疾病的奥秘。现在我们知道，生命的奥秘就在这个相互作用的丛林中。因此，我们需要找到罗塞塔石碑，即对系统生物学这个丛林的解释。我们需要找到，也许是曲折的，理解和干预的途径。系统生物化学是一个很好的起点，因为它有一个立足点，即进入的东西必须出来。在本文中，我们回顾了两种策略，它们着眼于控制和调节。我们讨论了控制和调节之间的区别，并证明了它们之间的关系。
