Krasnoyarsk State Medical University, Russia.
J Neurol Sci. 2010 Dec 15;299(1-2):39-41. doi: 10.1016/j.jns.2010.08.057. Epub 2010 Sep 22.
Type 2 diabetes mellitus and hypertension are two widely spread diseases among the adults that are known to be risk factors for vascular disease. They are highly related such that comorbidity is common. The purpose of the present study was to investigate the comorbid effects of type 2 diabetes and hypertension on cognitive decline. One hundred and thirteen patients with type 2 diabetes (women, age 56±7.4 years, diabetes duration 8±6.7 years, hypertension duration 13.4±7.7 years) were assessed for cognitive impairment (CI) in comparison with 27 diabetes patients without hypertension (women, age 53±7.45 years, diabetes duration 4.4±5.6 years), all non-demented at baseline. Patients were screened for cognitive dysfunction with the Mini Mental State Examination (MMSE), a clock-drawing test (CDT) and Frontal Assessment Battery (FAB). We assessed history of DM and hypertension by interview. 87% of women with diabetes and hypertension and 70% of normotensive diabetic patients had cognitive impairment (p=0.0282), of mild and subtle degree. The frequency of alterations in the FAB was higher in subjects with diabetes and hypertension (48%) compared to normotensive diabetic patients (26%) p=0.0402. Our results show that people with diabetes type 2 and hypertension demonstrate greater cognitive changes as compared to normotensive diabetic patients.
2 型糖尿病和高血压是成年人中两种广泛传播的疾病，已知它们是血管疾病的危险因素。它们之间高度相关，因此合并症很常见。本研究的目的是研究 2 型糖尿病和高血压合并对认知能力下降的影响。我们评估了 113 名患有 2 型糖尿病的患者（女性，年龄 56±7.4 岁，糖尿病病程 8±6.7 年，高血压病程 13.4±7.7 年）是否存在认知障碍（CI），并与 27 名无高血压的糖尿病患者（女性，年龄 53±7.45 岁，糖尿病病程 4.4±5.6 年）进行了比较，所有患者在基线时均未患有痴呆症。患者通过简易精神状态检查（MMSE）、画钟测验（CDT）和额叶评估量表（FAB）进行认知功能障碍筛查。我们通过访谈评估 DM 和高血压病史。患有糖尿病和高血压的女性中有 87%和无高血压的糖尿病患者中有 70%存在认知障碍（p=0.0282），程度为轻度和轻微。与无高血压的糖尿病患者（26%）相比，患有糖尿病和高血压的患者中 FAB 改变的频率更高（48%），p=0.0402。我们的研究结果表明，与无高血压的糖尿病患者相比，患有 2 型糖尿病和高血压的患者表现出更大的认知变化。
