Institut Pasteur, Toxines et Pathogénie Bactérienne, Département de Microbiologie, 28 rue du Dr Roux, 75724 Paris cedex 15, France.
Res Microbiol. 2010 Nov;161(9):735-42. doi: 10.1016/j.resmic.2010.09.006. Epub 2010 Sep 21.
Fifteen years ago, AtxA was isolated as a toxin gene activator and five years later it was shown to be a Bacillus anthracis master regulator. AtxA controls the expression of more than a hundred genes belonging to all genetic elements, the chromosome and both virulence plasmids, including those encoding the major virulence factors. AtxA can activate or repress gene expression. The mechanism by which AtxA exerts its control is unknown; it is indirect on some genes but may be direct on others. The expression of many AtxA-controlled genes is induced by the presence of bicarbonate/CO(2). AtxA links the metabolic state and virulence gene expression.
十五年前，AtxA 被分离为一种毒素基因激活剂，五年后，它被证明是炭疽杆菌的主要调控因子。AtxA 控制着超过一百个基因的表达，这些基因属于所有遗传元件，包括染色体和两个毒力质粒，以及编码主要毒力因子的基因。AtxA 可以激活或抑制基因表达。AtxA 发挥其控制作用的机制尚不清楚；在某些基因上是间接的，但在其他基因上可能是直接的。许多 AtxA 控制的基因的表达是由碳酸氢盐/CO(2)的存在诱导的。AtxA 将代谢状态和毒力基因表达联系起来。
