种族和性别并不是肾移植后移植物丢失的独立危险因素。

Race and gender are not independent risk factors of allograft loss after kidney transplantation.

机构信息

Department of Surgery, Tulane University School of Medicine, New Orleans, LA 70112-2669, USA.

出版信息

Am J Surg. 2011 Apr;201(4):463-7. doi: 10.1016/j.amjsurg.2010.01.032. Epub 2010 Sep 22.

DOI:10.1016/j.amjsurg.2010.01.032

PMID:20864077

Abstract

BACKGROUND

Little is known about the impact of gender on kidney allograft survival in black recipients.

METHODS

A total of 805 kidney transplant recipients were reviewed retrospectively.

RESULTS

All blacks compared with all whites had significantly reduced graft survival at 1, 2, and 3 years (89%, 84%, 82% vs 93%, 89%, 87%, respectively, log-rank P = .03). After stratification by race and gender, black females showed the worst graft survival. When black females were excluded, allograft survival between black males and all whites were similar. Black females carried more risk factors for graft loss. Compared with all others, the unadjusted hazard ratio of graft loss for black females was 1.67 (P < .01; 95% confidence interval, 1.15-2.43), but the adjusted hazard ratio was 1.47 (P = .07, 95% confidence interval, .98-2.23).

CONCLUSIONS

Race and gender in a multivariate analysis are not statistically significant independent risk factors for poor allograft outcomes.

摘要

背景

关于性别对黑人受者肾移植存活率的影响知之甚少。

方法

回顾性分析了 805 例肾移植受者。

结果

与所有白人相比，所有黑人在 1、2、3 年时移植物存活率显著降低（分别为 89%、84%、82%对 93%、89%、87%，对数秩检验 P =.03）。按种族和性别分层后，黑人女性的移植物存活率最差。排除黑人女性后，黑人男性与所有白人的移植物存活率相似。黑人女性发生移植物丢失的风险因素更多。与其他所有人相比，黑人女性发生移植物丢失的未调整风险比为 1.67（P <.01；95%置信区间，1.15-2.43），但调整后的风险比为 1.47（P =.07，95%置信区间，0.98-2.23）。