Griffith University, Brisbane, 4111, Queensland, Australia.
J Subst Abuse Treat. 2011 Jan;40(1):95-101. doi: 10.1016/j.jsat.2010.08.002. Epub 2010 Sep 22.
Relatively little is known about the clinical course of symptoms in patients with a substance-induced psychosis (SIP) compared with those with a primary psychotic disorder (PPD). In this study, symptoms associated with psychosis were monitored across admission in two groups of patients: those with SIP (amphetamines or cannabis; n = 47) and those with PPD (n = 51). Sixty-two percent of patients were first admissions, 23% had one previous admission, and a further 14% had had two previous admissions. Symptoms were monitored using the Brief Psychiatric Rating Scale. Scores on the positive symptoms scale, negative symptoms scale, manic excitement, and negative mood were reported as was the extent of observed disturbed behavior at admission and then at Days 4/5, 8/9, 15/16, 22/23, 29/30, 36/37, 43/44, and 50/51. Patients with a SIP experienced more severe mania and disturbed behavior at admission than those with a PPD. However, these symptoms abated more rapidly for the SIP group during admission. Although positive symptom scores were equally high at admission for both groups, there was a more rapid abatement of these symptoms in the SIP group. Finally, negative symptoms were lower in the SIP group at admission and at Days 50/51, although the decline in symptoms was comparable in both groups.
与原发性精神病障碍（PPD）患者相比，物质所致精神病（SIP）患者的症状临床病程相对知之甚少。在这项研究中，对两组患者入院时的精神病相关症状进行了监测：一组为 SIP 患者（安非他命或大麻；n = 47），另一组为 PPD 患者（n = 51）。62%的患者为首次入院，23%的患者有一次既往入院，14%的患者有两次既往入院。使用简明精神病评定量表监测症状。报告了阳性症状量表、阴性症状量表、躁狂兴奋和阴性情绪的评分，以及入院时和第 4/5、8/9、15/16、22/23、29/30、36/37、43/44 和 50/51 天观察到的紊乱行为的严重程度。SIP 组患者入院时的躁狂和紊乱行为比 PPD 组更严重。然而，在住院期间，SIP 组的这些症状更快地减轻。尽管两组患者入院时的阳性症状评分同样高，但 SIP 组的这些症状更快地减轻。最后，SIP 组患者入院时和第 50/51 天的阴性症状较低，尽管两组的症状减轻程度相当。
