在伴刀豆球蛋白A刺激的大鼠胸腺细胞中，鸟氨酸脱羧酶的早期诱导与肌醇磷酸积累同时发生。

Early induction of ornithine decarboxylase occurs simultaneously with inositol phosphate accumulation in concanavalin A-stimulated rat thymocytes.

作者信息

Valette L, Fonlupt P, Prigent A F, Macovschi O, Lagarde M

机构信息

Institute National de la Santé et de la Recherche Médicale U205, Laboratoire de Chimie Biologique, Villeurbanne, France.

出版信息

Immunol Lett. 1990 Dec;26(3):233-7. doi: 10.1016/0165-2478(90)90152-g.

DOI:10.1016/0165-2478(90)90152-g

PMID:2086451

Abstract

Stimulation of rat thymocytes with the lectin ConA produced an early peak of ornithine decarboxylase (ODC) activity within 10 min. This ODC induction appeared as early as the well-known inositol phosphate accumulation following mitogenic stimulation, and may be part of the signal transduction mechanism. The distribution of counts among the inositol phosphates was constant during the overall time of Concanavalin A (ConA) stimulation. We conclude that early induction of pre-existing ODC may be independent of protein kinase C action.

摘要

用凝集素伴刀豆球蛋白A（ConA）刺激大鼠胸腺细胞，在10分钟内鸟氨酸脱羧酶（ODC）活性出现早期峰值。这种ODC诱导与促有丝分裂刺激后众所周知的肌醇磷酸积累一样早出现，并且可能是信号转导机制的一部分。在伴刀豆球蛋白A（ConA）刺激的整个过程中，肌醇磷酸之间的计数分布是恒定的。我们得出结论，预先存在的ODC的早期诱导可能独立于蛋白激酶C的作用。