Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
Blood. 2010 Dec 16;116(25):5748-51. doi: 10.1182/blood-2010-07-295436. Epub 2010 Sep 23.
Studies in mice have shown that proinflammatory Th17 cells can cause acute graft-versus-host disease (aGVHD) related tissue damage; however, whether they play a role in human aGVHD remains unclear. In a prospective study, we measured the proportion of Th17 cells in the blood and skin of patients at the onset of aGVHD. We found no difference in the proportion or amount of IL-17 produced by T cells in the blood of patients with aGVHD (n = 20) compared with time-matched patients without GVHD (n = 14). Moreover, Th17 cells were not increased in the skin of patients with cutaneous aGVHD (n = 7) compared with healthy controls (n = 10). In contrast, we found significantly more interferon-γ-producing T cells in the skin of patients with aGVHD compared with controls. These data support the long-standing paradigm that tissue localized interferon-γ-producing cells are the perpetrators of aGVHD.
在小鼠研究中表明，促炎型 Th17 细胞可能导致急性移植物抗宿主病（aGVHD）相关的组织损伤；然而，它们在人类 aGVHD 中是否起作用仍不清楚。在一项前瞻性研究中，我们测量了发生 aGVHD 时患者血液和皮肤中 Th17 细胞的比例。我们发现，与无 GVHD 的时间匹配患者（n = 14）相比，aGVHD 患者（n = 20）血液中的 T 细胞产生的 IL-17 比例或数量没有差异。此外，与健康对照组（n = 10）相比，皮肤 aGVHD 患者（n = 7）的 Th17 细胞并未增加。相比之下，我们发现与对照组相比，aGVHD 患者皮肤中产生干扰素-γ的 T 细胞明显更多。这些数据支持了一个长期存在的范例，即组织中定位的产生干扰素-γ的细胞是 aGVHD 的罪魁祸首。
