Sachdev M S, Kumar H, Jain A K, Goulatia R K, Misra N K
Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi.
Indian J Ophthalmol. 1990 Oct-Dec;38(4):151-2.
A case is reported of a 9-year old male who presented with abnormal behaviour and progressive diminution of vision. Pupils were middilated in both eyes but the pupillary reflexes were preserved. Fundus examination revealed a bilateral optic atrophy and radiological investigations showed a bilateral occipital calcification. We hereby document a case of retrograde transsynaptic neuronal degeneration of the visual system secondary to bilateral occipital lesions. Transsynapptic neuronal degeneration of optic nerves consequent to occipital lobe lesions is a rare phenomenon. Experimentally occipital lobe ablation in non-human primates has been shown to result in optic atrophy. Herein, we document a case of retrograde transsynaptic neuronal degeneration of the visual system secondary to bilateral occipital lesions.
报告了一例9岁男性患者，其表现为行为异常和视力进行性减退。双眼瞳孔中度散大，但瞳孔反射保留。眼底检查显示双侧视神经萎缩，影像学检查显示双侧枕叶钙化。我们在此记录了一例继发于双侧枕叶病变的视觉系统逆行性跨突触神经元变性病例。枕叶病变导致的视神经跨突触神经元变性是一种罕见现象。实验表明，在非人类灵长类动物中进行枕叶切除会导致视神经萎缩。在此，我们记录了一例继发于双侧枕叶病变的视觉系统逆行性跨突触神经元变性病例。
