Bando Hiroki, Murao Yoshinori, Aoyagi Ui, Hirakawa Akihiko, Iwase Masaaki, Nakatani Toshio
Emergency and Critical Care Center, Kansai Medical University, Osaka, Japan.
Chudoku Kenkyu. 2010 Sep;23(3):246-9.
A 65-year-old female was transferred to our emergency and critical care center after taking two kinds of commercially available glyphosate herbicide products. On admission, her conscious level was depressed to Glasgow Coma Scale E3, V2, and M6. Vital signs were as follows ; blood pressure 83/33mmHg, pulse 59/min, and respiratory rate was 24/min. Arterial blood gas analysis showed metabolic acidosis and an extreme hyperkalemia of 9.22 mEq/L. Electrocardiogram showed absence of P wave and a tall, tapering T wave. On admission, gastric lavage was followed by an intragastric administration of activated charcoal together with cathartic. Immediately after recognition of hyperkalemia, sodium bicarbonate, glucose plus insulin, and calcium gluconate were also administered intravenously. Five hours later, plasma concentration of potassium decreased to 4.31 mEq/L, and the patient discharged on day 10. Later, it was disclosed that the new Roundup Maxload contains high concentration of glyphosate potassium.
In case of Roundup poisoning, we have to take it consideration that the poisoning may results in a hyperkalemia.
一名65岁女性在服用了两种市售草甘膦除草剂产品后被转至我们的急诊与重症监护中心。入院时,她的意识水平降至格拉斯哥昏迷量表评分为E3、V2和M6。生命体征如下:血压83/33mmHg,脉搏59次/分钟,呼吸频率24次/分钟。动脉血气分析显示代谢性酸中毒以及血钾极度升高至9.22 mEq/L。心电图显示P波消失且T波高耸、顶端变窄。入院后,先进行了洗胃,随后胃内给予活性炭并加用泻药。在确认高钾血症后,立即静脉给予碳酸氢钠、葡萄糖加胰岛素以及葡萄糖酸钙。5小时后,血钾浓度降至4.31 mEq/L,患者于第10天出院。后来发现,新款农达Maxload含有高浓度的草甘膦钾。
在草甘膦中毒的情况下,我们必须考虑到中毒可能导致高钾血症。