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脂质双分子层膜在熔点转变时的离子通道样行为。

Ion-channel-like behavior in lipid bilayer membranes at the melting transition.

作者信息

Gallaher Jill, Wodzińska Katarzyna, Heimburg Thomas, Bier Martin

机构信息

Department of Physics, East Carolina University, Greenville, North Carolina 27858, USA.

出版信息

Phys Rev E Stat Nonlin Soft Matter Phys. 2010 Jun;81(6 Pt 1):061925. doi: 10.1103/PhysRevE.81.061925. Epub 2010 Jun 30.

Abstract

It is well known that at the gel-liquid phase-transition temperature a lipid bilayer membrane exhibits an increased ion permeability. We analyze the quantized currents in which the increased permeability presents itself. The open time histogram shows a "-3/2" power law which implies an open-closed transition rate that decreases like k(t)∝t(-1) as time evolves. We propose a "pore freezing" model to explain the observations. We discuss how this model also leads to the 1/fα noise that is commonly observed in currents across biological and artificial membranes.

摘要

众所周知,在凝胶 - 液相转变温度下,脂质双分子层膜表现出离子渗透性增加。我们分析了渗透率增加时出现的量子化电流。开放时间直方图显示出“-3/2”幂律,这意味着随着时间的推移,开闭转换速率像k(t)∝t(-1)一样下降。我们提出了一个“孔冻结”模型来解释这些观察结果。我们讨论了这个模型如何也导致了在生物膜和人工膜电流中普遍观察到的1/fα噪声。

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