Ruegg C L, Strand M
Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
J Interferon Res. 1990 Dec;10(6):621-6. doi: 10.1089/jir.1990.10.621.
We have identified a 10-amino acid sequence (amino acid, 9-18) from interferon-alpha (IFN-alpha) that when presented as a synthetic peptide inhibits both the proliferation of the Daudi lymphoblastoid cell line and the antigen receptor-stimulated proliferation of fresh human T lymphocytes. This sequence, which was identified by virtue of its sequence similarity (70% identity) to the immunosuppressive sequence of the retroviral transmembrane protein p15E, represents the smallest fragment of IFN-alpha that has been shown to date to be biologically active.
我们已从α干扰素（IFN-α）中鉴定出一段10个氨基酸的序列（第9至18位氨基酸），当该序列以合成肽形式呈现时，可抑制多毛细胞白血病细胞系的增殖以及新鲜人T淋巴细胞受抗原受体刺激后的增殖。该序列因其与逆转录病毒跨膜蛋白p15E的免疫抑制序列具有序列相似性（70%同源性）而被鉴定出来，它是迄今为止已被证明具有生物活性的IFN-α最小片段。
