Satoh Y, Iwata S, Akita H, Sunakawa K
Department of Pediatrics, Ohta General Hospital.
Jpn J Antibiot. 1990 Oct;43(10):1796-805.
Clinical evaluations of cefdinir (CFDN, FK482) were carried out. The obtained results are summarized as follows. 1. Clinical responses to CFDN of 43 patients with pediatric infections were excellent in 23, good in 15, fair in 4 and poor in 1. The overall efficacy rate was 88%. 2. Bacteriologically, the eradication rate for 34 isolates presumed to be pathogens was evaluated and the eradication rate was 85.3%. 3. Side effects observed were diarrhea in 4 of 48 patients. The incidence was 8.3%. Abnormal laboratory findings were an elevation of GOT, an elevation of eosinophils and an increase in platelet counts. The results suggested that CFDN might be a very useful and safe drug for the treatment of pediatric infections.
对头孢地尼（CFDN，FK482）进行了临床评估。所得结果总结如下。1. 43例儿科感染患者使用CFDN后的临床反应为：23例优秀，15例良好，4例中等，1例差。总有效率为88%。2. 从细菌学角度，对34株推测为病原体的菌株的根除率进行了评估，根除率为85.3%。3. 观察到的副作用为：48例患者中有4例出现腹泻。发生率为8.3%。实验室检查异常包括谷草转氨酶升高、嗜酸性粒细胞增多和血小板计数增加。结果表明，CFDN可能是治疗儿科感染非常有用且安全的药物。
