Department of Obstetrics & Gynecology, Northwestern University, Feinberg School of Medicine, 680 North Lake Shore Drive, Chicago, IL60611, USA.
Dermatol Ther. 2010 Sep-Oct;23(5):514-22. doi: 10.1111/j.1529-8019.2010.01354.x.
With the loss of estrogen that occurs with menopause, physiologic and structural changes occur within the vulvovaginal mucosa that lead to a condition commonly called atrophic vaginitis. Although mild genital changes occur in most women, 10-47% of postmenopausal women will develop one or more debilitating symptoms that include vulvovaginal dryness, dyspareunia, vulvar itching or pain, recurrent urinary tract infections, as well as abnormal vaginal discharge. Topical estrogen replacement therapies reverse these mucosal changes and are effective treatments for the symptoms of atrophic vaginitis. Vaginal moisturizers and lubricants also provide symptomatic relief for vaginal dryness and dyspareunia, respectively.
随着绝经后雌激素的流失，外阴阴道黏膜会发生生理性和结构性变化，导致一种通常称为萎缩性阴道炎的疾病。尽管大多数女性都会出现轻微的生殖器变化，但 10-47%的绝经后女性会出现一种或多种使人虚弱的症状，包括外阴阴道干燥、性交困难、外阴瘙痒或疼痛、复发性尿路感染以及异常阴道分泌物。局部雌激素替代疗法可逆转这些黏膜变化，是治疗萎缩性阴道炎症状的有效方法。阴道保湿剂和润滑剂也分别为阴道干燥和性交困难提供症状缓解。
