Department of Dermatology, S. Elia Hospital, Via Luigi Russo 6, Caltanissetta (CL), Italy.
Dermatol Ther. 2010 Sep-Oct;23(5):541-3. doi: 10.1111/j.1529-8019.2010.01357.x.
Pyoderma gangrenosum (PG) is a rare, noninfectious, neutrophilic dermatosis of unknown origin that is associated with systemic diseases in 50% of cases. The authors present a case of a 54-year-old man patient with refractory to conventional treatment PG associated with ulcerative colitis and psoriasis, which showed a successful response to treatment with infliximab, a chimeric monoclonal antibody that inhibits tumor necrosis factor alpha (TNF-α). This case report shows the frequent difficulty in the therapeutic approach of PG, especially if associated with underlying disease, and necessity to apply new agents, such as a novel application of the TNF-α inhibitors, in relationship to the recent pathogenic knowledge.
坏疽性脓皮病（PG）是一种罕见的、非传染性的中性粒细胞性皮肤病，病因不明，50%的病例与系统性疾病有关。作者报告了一例 54 岁男性患者，患有难治性 PG，与溃疡性结肠炎和银屑病有关，用英夫利昔单抗（一种抑制肿瘤坏死因子-α（TNF-α）的嵌合单克隆抗体）治疗后取得了成功的反应。本病例报告显示了 PG 的治疗方法经常存在困难，特别是如果与潜在疾病有关，并且需要应用新的药物，如 TNF-α抑制剂的新应用，与最近的发病机制知识有关。
