• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

抗肿瘤坏死因子α单克隆抗体(英夫利昔单抗)用于治疗与克罗恩病相关的坏疽性脓皮病。

Anti-tumor necrosis factor alpha monoclonal antibody (infliximab) for the treatment of Pyoderma gangrenosum associated with Crohn's disease.

作者信息

Zaccagna Alessandro, Bertone Alberto, Puiatti Paolo, Picciotto Franco, Sprujevnik Tatiana, Santucci Renato, Rossini Francesco Paolo

机构信息

Institute for Cancer Research and Treatment (IRCC), Operative Unit of Dermatologic Surgery, Str.Prov.142, Km 3.95, 10060 Candiolo, Italy.

出版信息

Eur J Dermatol. 2003 May-Jun;13(3):258-60.

PMID:12804985
Abstract

Here we report a case of Pyoderma gangrenosum (PG) associated with Crohn's disease successfully treated with infliximab. The efficacy of this drug in many inflammatory diseases has already been reported, but its use in PG has only been seen in very few cases. Our study confirms that this therapy is a valid alternative solution for treating PG, which is often unresponsive to conventional therapies.

摘要

在此,我们报告一例用英夫利昔单抗成功治疗的与克罗恩病相关的坏疽性脓皮病(PG)病例。该药物在许多炎症性疾病中的疗效已有报道,但其在PG中的应用仅见于极少数病例。我们的研究证实,这种疗法是治疗PG的一种有效的替代解决方案,PG通常对传统疗法无反应。

相似文献

1
Anti-tumor necrosis factor alpha monoclonal antibody (infliximab) for the treatment of Pyoderma gangrenosum associated with Crohn's disease.抗肿瘤坏死因子α单克隆抗体(英夫利昔单抗)用于治疗与克罗恩病相关的坏疽性脓皮病。
Eur J Dermatol. 2003 May-Jun;13(3):258-60.
2
Infliximab for treatment of pyoderma gangrenosum associated with clinically inactive Crohn's disease. A case report.英夫利昔单抗治疗与临床非活动期克罗恩病相关的坏疽性脓皮病:一例报告
Rom J Gastroenterol. 2005 Dec;14(4):401-3.
3
Use of infliximab in pyoderma gangrenosum.英夫利昔单抗在坏疽性脓皮病中的应用。
Australas J Dermatol. 2007 May;48(2):95-8. doi: 10.1111/j.1440-0960.2007.00344.x.
4
Improvement of Pyoderma gangrenosum and psoriasis associated with Crohn disease with anti-tumor necrosis factor alpha monoclonal antibody.使用抗肿瘤坏死因子α单克隆抗体改善克罗恩病相关的坏疽性脓皮病和银屑病。
Arch Dermatol. 2001 Jul;137(7):930-3.
5
Favorable response to infliximab treatment in a patient with active Crohn disease and pyoderma gangrenosum.一名患有活动性克罗恩病和坏疽性脓皮病的患者对英夫利昔单抗治疗反应良好。
Scand J Gastroenterol. 2002 Jul;37(7):863-5.
6
Improvement of idiopathic pyoderma gangrenosum during treatment with anti-tumor necrosis factor alfa monoclonal antibody.使用抗肿瘤坏死因子α单克隆抗体治疗期间特发性坏疽性脓皮病的改善情况。
Int J Low Extrem Wounds. 2007 Jun;6(2):108-13. doi: 10.1177/1534734607300912.
7
Infliximab for the treatment of disseminated pyoderma gangrenosum associated with ulcerative colitis. Case report and literature review.英夫利昔单抗治疗与溃疡性结肠炎相关的播散性坏疽性脓皮病。病例报告及文献综述。
Dermatology. 2007;215(3):245-51. doi: 10.1159/000106584.
8
Infliximab for treatment of resistant pyoderma gangrenosum associated with Crohn's disease.英夫利昔单抗治疗与克罗恩病相关的难治性坏疽性脓皮病。
Acta Dermatovenerol Alp Pannonica Adriat. 2006 Dec;15(4):173-7.
9
Therapeutic hotline. Infliximab for treatment of resistant pyoderma gangrenosum associated with ulcerative colitis and psoriasis. A case report.治疗热线。英夫利昔单抗治疗溃疡性结肠炎和银屑病相关难治性坏疽性脓皮病。病例报告。
Dermatol Ther. 2010 Sep-Oct;23(5):541-3. doi: 10.1111/j.1529-8019.2010.01357.x.
10
Successful treatment with infliximab for refractory pyoderma gangrenosum associated with inflammatory bowel disease.英夫利昔单抗成功治疗与炎症性肠病相关的难治性坏疽性脓皮病。
J Dermatol. 2012 Jun;39(6):576-8. doi: 10.1111/j.1346-8138.2011.01346.x. Epub 2011 Sep 29.

引用本文的文献

1
Extraintestinal Manifestations of Inflammatory Bowel Disease.炎症性肠病的肠外表现
Inflamm Bowel Dis. 2015 Aug;21(8):1982-92. doi: 10.1097/MIB.0000000000000392.
2
Canadian Association of Gastroenterology Clinical Practice Guidelines: The use of tumour necrosis factor-alpha antagonist therapy in Crohn's disease.加拿大胃肠病学协会临床实践指南:肿瘤坏死因子-α拮抗剂疗法在克罗恩病中的应用
Can J Gastroenterol. 2009 Mar;23(3):185-202. doi: 10.1155/2009/201430.
3
Extensive ulcerations due to pyoderma gangrenosum in a child with juvenile systemic lupus erythematosus and C1q deficiency.
一名患有青少年系统性红斑狼疮和C1q缺乏症的儿童因坏疽性脓皮病出现广泛溃疡。
Ann Saudi Med. 2008 Nov-Dec;28(6):466-8. doi: 10.5144/0256-4947.2008.466.
4
Pyoderma gangrenosum developing during therapy with TNF-alpha antagonists in a patient with rheumatoid arthritis.一名类风湿关节炎患者在接受肿瘤坏死因子-α拮抗剂治疗期间发生坏疽性脓皮病。
Clin Rheumatol. 2007 Dec;26(12):2205-2206. doi: 10.1007/s10067-007-0733-8. Epub 2007 Sep 18.
5
Adalimumab therapy for recalcitrant pyoderma gangrenosum.阿达木单抗治疗顽固性坏疽性脓皮病。
J Burns Wounds. 2006 Nov 20;5:e8.
6
Extraintestinal complications of inflammatory bowel disease.炎症性肠病的肠外并发症
Curr Gastroenterol Rep. 2003 Dec;5(6):512-7. doi: 10.1007/s11894-003-0042-6.