Powell S M, Tremlett M, Bosman D A
Department of Otolaryngology, James Cook University Hospital, Middlesbrough, UK.
J Laryngol Otol. 2011 Feb;125(2):193-8. doi: 10.1017/S0022215110001635. Epub 2010 Sep 27.
To assess the quality of life of UK children with sleep-disordered breathing undergoing adenotonsillectomy, by using the Obstructive Sleep Apnoea 18 questionnaire and determining score changes and effect sizes.
Prospective, longitudinal study.
The otolaryngology department of a university teaching hospital in Northern England.
Twenty-eight children for whom adenotonsillectomy was planned as treatment for sleep-disordered breathing, and who had either a clinical history consistent with obstructive sleep apnoea or a polysomnographic diagnosis.
The Obstructive Sleep Apnoea 18 questionnaire, a previously validated, disease-specific quality of life assessment tool; changes in questionnaire scores and effect sizes were assessed.
The Obstructive Sleep Apnoea 18 questionnaire was administered to each child's parent pre-operatively, then again at the follow-up appointment. Questionnaire scores ranged from 1 to 7. Score changes were analysed using the paired t-test; effect sizes were calculated using 95 per cent confidence intervals.
Complete data were obtained for 22 children (mean age, 61 months). Ten had undergone pre-operative polysomnography. Twenty-one children underwent adenotonsillectomy (one underwent tonsillectomy). Median follow up was eight weeks (interquartile range, six to 11 weeks). Following surgery, the overall mean score improvement was 2.6 (p < 0.0001) and the mean effect size 2.4 (95 per cent confidence interval 1.9 to 2.8). There were significant improvements in each of the individual questionnaire domains, i.e. sleep disturbance (mean score change 3.9, p < 0.0001), physical suffering (2.2, p < 0.0001), emotional distress (2.0, p = 0.0001), daytime problems (1.8, p = 0.0001) and caregiver concerns (2.6, p < 0.0001).
In these children with sleep-disordered breathing treated by adenotonsillectomy, Obstructive Sleep Apnoea 18 questionnaire results indicated significantly improved mean score changes and effect sizes across all questionnaire domains, comparing pre- and post-operative data.
通过使用阻塞性睡眠呼吸暂停18项问卷并确定得分变化和效应量，评估在英国接受腺样体扁桃体切除术的儿童睡眠呼吸障碍患者的生活质量。
前瞻性纵向研究。
英格兰北部一所大学教学医院的耳鼻喉科。
28名计划接受腺样体扁桃体切除术以治疗睡眠呼吸障碍的儿童，他们要么有与阻塞性睡眠呼吸暂停相符的临床病史，要么有多导睡眠图诊断。
阻塞性睡眠呼吸暂停18项问卷，一种先前已验证的、针对特定疾病的生活质量评估工具；评估问卷得分变化和效应量。
在术前向每个孩子的家长发放阻塞性睡眠呼吸暂停18项问卷，在随访预约时再次发放。问卷得分范围为1至7分。使用配对t检验分析得分变化；使用95%置信区间计算效应量。
获得了22名儿童（平均年龄61个月）的完整数据。其中10名儿童术前接受了多导睡眠图检查。21名儿童接受了腺样体扁桃体切除术（1名接受了扁桃体切除术）。中位随访时间为8周（四分位间距为6至11周）。术后，总体平均得分改善了2.6分（p<0.0001），平均效应量为2.4（95%置信区间为1.9至2.8）。问卷的各个领域均有显著改善，即睡眠障碍（平均得分变化3.9分，p<0.0001）、身体痛苦（2.2分，p<0.0001）、情绪困扰（2.0分，p=0.0001）、日间问题（1.8分，p=0.0001）和照顾者担忧（2.6分，p<0.0001）。
在这些接受腺样体扁桃体切除术治疗睡眠呼吸障碍的儿童中，阻塞性睡眠呼吸暂停18项问卷结果表明，与术前数据相比，术后所有问卷领域的平均得分变化和效应量均有显著改善。
