Department of Psychiatry, Ludwig Maximilians University, Munich, Germany.
Prog Neuropsychopharmacol Biol Psychiatry. 2011 Jan 15;35(1):74-7. doi: 10.1016/j.pnpbp.2010.08.029. Epub 2010 Sep 22.
Age, haloperidol plasma levels and sex are associated with haloperidol induced motor side effects according to some lines of evidence, even though some conflicting findings mandate further research. We here report that age and sex were associated with dystonia during the early phases of treatment (p = 0.0006 and p = 0.008 respectively), but are overall poor predictors of the Extrapyramidal Symptom Rating Scale scores' variation over time (first month of treatment) in a sample of 60 acutely ill haloperidol treated psychotic patients. We conclude that age, sex and haloperidol plasma levels are not robust predictors of haloperidol induced motor side effects. Nonetheless, some limits of the study including the small sample size and the imputation of missing data could have diminished the power of detecting minor impacts of the investigated clinical predictors of the haloperidol induced motor side effects.
根据一些证据，年龄、氟哌啶醇血浆水平和性别与氟哌啶醇引起的运动副作用有关，尽管一些相互矛盾的发现需要进一步研究。我们在这里报告，年龄和性别与治疗早期的肌张力障碍有关（p=0.0006 和 p=0.008），但在 60 例急性氟哌啶醇治疗精神疾病患者的样本中，它们总体上并不能很好地预测锥体外系症状评定量表评分随时间（治疗第一个月）的变化。我们的结论是，年龄、性别和氟哌啶醇血浆水平不是氟哌啶醇引起的运动副作用的可靠预测因素。尽管如此，该研究还是存在一些局限性，包括样本量小和缺失数据的推断，这可能降低了检测所研究的氟哌啶醇引起的运动副作用的临床预测因子的较小影响的能力。
