通过高压液相色谱分析法对阿普溴尔、溴米索伐及其主要代谢产物进行分离和定量测定。
Separation and quantitative determination of acecarbromal, carbromal, and bromisoval as well as their main metabolites by means of high-pressure liquid chromatographic analysis.
作者信息
Höbel M, Bender G
出版信息
Arch Toxicol. 1977 Aug 9;37(4):307-12. doi: 10.1007/BF00330822.
PMID:20869
Abstract
A method is described to separate and quantitatively determine bromoureides and their bromo- and non-bromo-metabolites by means of high-pressure liquid chromatography. This method allows simultaneous measurement of these substances after intake of therapeutic as well as toxic doses.
摘要
本文描述了一种通过高压液相色谱法分离和定量测定溴脲类及其溴代和非溴代代谢物的方法。该方法能够在摄入治疗剂量和中毒剂量后同时测定这些物质。
相似文献
1
Separation and quantitative determination of acecarbromal, carbromal, and bromisoval as well as their main metabolites by means of high-pressure liquid chromatographic analysis.通过高压液相色谱分析法对阿普溴尔、溴米索伐及其主要代谢产物进行分离和定量测定。
Arch Toxicol. 1977 Aug 9;37(4):307-12. doi: 10.1007/BF00330822.
2
[APROPOS OF THE QUANTITATIVE DETERMINATION OF BROMISOVAL AND CARBROMAL BY MEASURING THE SURFACE TENSION].[关于通过测量表面张力对溴米索伐和溴醛进行定量测定]
Aptechn Delo. 1964 Jan-Feb;13:72-5.
3
Comparison of the bromureide sedative-hypnotic drugs, bromvaletone (bromisoval) and carbromal, and their chloro analogues in mice.溴化物镇静催眠药物、溴戊酮（溴异戊酰脲）和溴米那，以及它们的氯代类似物在小鼠体内的比较。
Clin Exp Pharmacol Physiol. 1976 Sep-Oct;3(5):443-7. doi: 10.1111/j.1440-1681.1976.tb00621.x.
4
Determination of monoureides in biological fluids by high-pressure-liquid-chromatography.用高压液相色谱法测定生物体液中的单酰脲类化合物。
Arch Toxicol. 1978 Dec 28;41(3):187-93. doi: 10.1007/BF00354090.
5
Colorimetric determination of bromisoval and carbromal.溴异戊酰脲和溴米那的比色测定法。
Pol J Pharmacol Pharm. 1975 Nov-Dec;27(6):645-8.
6
[Pharmacokinetics and -dynamics of bromoureides].[溴脲类药物的药代动力学和药效动力学]
Dtsch Med Wochenschr. 1977 Oct 21;102(42):1530-1.
7
Simultaneous determination of bromvalerylurea, bromodiethylacetylurea, and allylisopropylacetylurea in serum and urine by high-performance liquid chromatography with a multiwavelength UV detector and thin-layer chromatography.采用带多波长紫外检测器的高效液相色谱法及薄层色谱法同时测定血清和尿液中的溴戊酰脲、溴二乙基乙酰脲和烯丙基异丙基乙酰脲。
J Anal Toxicol. 1991 May-Jun;15(3):123-5. doi: 10.1093/jat/15.3.123.
8
New bromisoval (bromural) metabolites in human urine: alpha-(cystein-S-yl)isovalerylurea, alpha-(N-acetylcystein-S-yl)isovalerylurea and alpha-(cysteamin-S-yl)isovaleric acid.人尿中新的溴米那（溴戊酰脲）代谢物：α-（半胱氨酸-S-基）异戊酰脲、α-（N-乙酰半胱氨酸-S-基）异戊酰脲和α-（半胱胺-S-基）异戊酸。
J Chromatogr. 1978 Jan 11;147:163-76. doi: 10.1016/s0021-9673(00)85128-6.
9
[Comparison of the cardiotoxic effects of carbromal, bromisoval and pentobarbital].[溴米那、溴异戊酰脲和戊巴比妥的心脏毒性作用比较]
Med Welt. 1978 Jul 28;29(29-30):1184-7.
10
Identification and differentiation of barbiturates, other sedative-hypnotics and their metabolites in urine integrated in a general screening procedure using computerized gas chromatography-mass spectrometry.在使用计算机化气相色谱 - 质谱联用的一般筛查程序中对尿液中的巴比妥类药物、其他镇静催眠药及其代谢物进行鉴定和区分。
J Chromatogr. 1990 Sep 14;530(2):307-26. doi: 10.1016/s0378-4347(00)82334-8.
引用本文的文献
1
Determination of monoureides in biological fluids by high-pressure-liquid-chromatography.用高压液相色谱法测定生物体液中的单酰脲类化合物。
Arch Toxicol. 1978 Dec 28;41(3):187-93. doi: 10.1007/BF00354090.
本文引用的文献
1
A metabolite of 'carbromal'.溴米那的一种代谢物。
Nature. 1960 Oct 1;188:58. doi: 10.1038/188058a0.
2
[Clinical features and treatment of carbromal poisoning].[溴米那中毒的临床特征与治疗]
Dtsch Med Wochenschr. 1972 Dec 8;97(49):1911-6. doi: 10.1055/s-0028-1107675.
3
Comparison of bromisoval and carbromal in the rat.溴米那和溴化钠在大鼠体内的比较。
J Pharm Pharmacol. 1969 May;21(5):287-92. doi: 10.1111/j.2042-7158.1969.tb08251.x.
4
[On the demonstration and quantitative determination of brominated urea derivatives in toxicology].[关于毒理学中溴化脲衍生物的鉴定及定量测定]
Arch Toxikol. 1967;22(5):404-9.
5
[Sensitive determination of bromocarbamides in body fluids using thin layer chromatography].[采用薄层色谱法对体液中溴代碳酰胺进行灵敏测定]
Z Klin Chem Klin Biochem. 1974 Apr;12(4):178-9.
6
[Investigations on the UV-photometric detection of recent ingestion of therapeutic and suicidal doses of carbromal (Adalin) in urine. II. Detection of bromides in chemical toxicology (author's transl)].[关于紫外线光度法检测尿液中近期摄入治疗剂量及自杀剂量溴米那（阿达林）的研究。II. 化学毒理学中溴化物的检测（作者译）]
Arch Toxikol. 1974 Feb 28;31(3):271-8.
7
[The clinical course of severe carbromal poisoning (author's transl)].重度溴米索伐中毒的临床病程（作者译）
Klin Wochenschr. 1974 Jan 1;52(1):39-49. doi: 10.1007/BF01468521.
8
[Studies on metabolism of bromourea derivatives. 1. In vitro degradation of carbromal and acetylcarbromal in rabbit liver].[溴脲衍生物的代谢研究。1. 卡溴脲和乙酰卡溴脲在兔肝脏中的体外降解]
Arzneimittelforschung. 1973 Aug;23(8):1021-3.
9
[Fatal poisonings with carbromal and bromisoval].[溴米那普鲁卡因和溴异戊酰脲致死性中毒]
Med Welt. 1973 Feb 9;24(6):212-4.
10
[Clinical studies on the habitual abuse of bromoureides].[溴脲类药物习惯性滥用的临床研究]
Beitr Gerichtl Med. 1975;33:214-8.
Zotero 插件