Tampere School of Public Health, University of Tampere, Tampere, Finland.
Maturitas. 2010 Dec;67(4):368-74. doi: 10.1016/j.maturitas.2010.08.007. Epub 2010 Sep 24.
The aim of this study is to report the prevalence of menopausal symptoms by severity among the Finnish female population and the association of their symptoms with lifestyle (smoking, use of alcohol, physical activity) and body mass index (BMI).
Health 2000 is a nationally representative population-based study of Finnish adults. Data were collected by home interview, three self-administered questionnaires and a clinical examination by a physician. This study included women aged 45-64 years (n=1427). All symptoms included menopause-specific symptoms. Both univariate analysis and a factor analysis based on symptom factors were performed by menopausal group. Multiple regression analysis included each symptom factor as a dependent variable and confounding and lifestyle factors (age, education, smoking, alcohol use, physical activity, BMI, use of hormonal replacement therapy (HRT) and chronic disease status).
Over one-third (38%) of the premenopausal, half of the perimenopausal, and 54% of both postmenopausal and hysterectomized women reported bothersome symptoms. The difference between pre- and perimenopausal women was largest and statistically most significant in the case of back pain and hot flushes. Physically active women reported fewer somatic symptoms than did women with a sedentary lifestyle. Smoking was not related to vasomotor symptoms.
Bothersome symptoms are common in midlife, regardless of menopausal status. Inverse association between physical activity and menopausal symptoms needs to be confirmed in randomized trials.
本研究旨在报告芬兰女性人群中绝经症状的严重程度分布,并探讨其与生活方式(吸烟、饮酒、体力活动)和体重指数(BMI)的关系。
健康 2000 研究是一项基于芬兰成年人的全国代表性人群研究。数据通过家庭访谈、三份自我管理问卷和医生临床检查收集。本研究纳入了 45-64 岁的女性(n=1427)。所有症状均包括绝经特异性症状。采用单因素分析和基于症状因素的因子分析方法,按绝经组进行分析。多因素回归分析将每个症状因素作为因变量,将混杂因素和生活方式因素(年龄、教育程度、吸烟、饮酒、体力活动、BMI、激素替代疗法(HRT)使用情况和慢性疾病状态)作为自变量。
三分之一以上(38%)的绝经前、一半的围绝经期和绝经后及子宫切除后的女性报告有困扰症状。绝经前和围绝经期女性之间的差异最大,且在背痛和热潮红方面具有统计学意义。与久坐不动的女性相比,体力活动的女性报告的躯体症状较少。吸烟与血管舒缩症状无关。
无论绝经状态如何,困扰症状在中年都很常见。体力活动与绝经症状之间的负相关关系需要在随机试验中得到证实。