Asclepios Research Project, INRIA, Sophia Antipolis, France.
Prog Biophys Mol Biol. 2010 Dec;103(2-3):185-96. doi: 10.1016/j.pbiomolbio.2010.09.005. Epub 2010 Oct 1.
Understanding and modeling liver biomechanics represents a significant challenge due to its complex nature. In this paper, we tackle this issue in the context of real-time surgery simulation where a compromise between biomechanical accuracy and computational efficiency must be found. We describe a realistic liver model including hyperelasticity, porosity and viscosity that is implemented within an implicit time integration scheme. To optimize its computation, we introduce the Multiplicative Jacobian Energy Decomposition (MJED) method for discretizing hyperelastic materials on linear tetrahedral meshes which leads to faster matrix assembly than the standard Finite Element Method. Visco-hyperelasticity is modeled by Prony series while the mechanical effect of liver perfusion is represented with a linear Darcy law. Dynamic mechanical analysis has been performed on 60 porcine liver samples in order to identify some viscoelastic parameters. Finally, we show that liver deformation can be simulated in real-time on a coarse mesh and study the relative effects of the hyperelastic, viscous and porous components on the liver biomechanics.
理解和建模肝脏生物力学是一个重大挑战,因为它的性质很复杂。在本文中,我们在实时手术模拟的背景下解决这个问题,在这个背景下,必须在生物力学准确性和计算效率之间找到一个折衷。我们描述了一个包括超弹性、多孔性和粘性的现实肝脏模型,该模型在隐式时间积分方案中实现。为了优化其计算,我们引入了乘法雅可比能量分解 (MJED) 方法,用于在线性四面体网格上离散超弹性材料,这导致比标准有限元方法更快的矩阵组装。粘弹性通过 Prony 级数建模,而肝脏灌注的力学效应则用线性达西定律表示。对 60 个猪肝脏样本进行了动态力学分析,以确定一些粘弹性参数。最后,我们表明可以在粗网格上实时模拟肝脏变形,并研究超弹性、粘性和多孔成分对肝脏生物力学的相对影响。