Mental Health Service, Atlanta Veterans Affairs Medical Center, Decatur, GA 30033, USA.
Schizophr Res. 2011 Feb;125(2-3):169-73. doi: 10.1016/j.schres.2010.08.041. Epub 2010 Sep 25.
Recent studies have implicated inappropriate engagement of functional brain networks in schizophrenia. This fMRI study examined task-induced activations and deactivations in 10 schizophrenia patients with prominent negative symptoms and 10 healthy controls during a simple target detection task. Group comparison revealed recruitment of distinct attentional networks during this task, with schizophrenia subjects activating the dorsal attention system and controls activating the executive network. Further, schizophrenia patients failed to deactivate posterior cingulate regions during the task, supporting recent studies of altered default mode processing. These findings support theories of dysfunctional recruitment of large-scale brain networks in schizophrenia.
最近的研究表明，精神分裂症患者的功能性大脑网络连接不当。这项 fMRI 研究使用简单的目标检测任务，对 10 名有明显阴性症状的精神分裂症患者和 10 名健康对照者进行了任务诱发激活和去激活的研究。组间比较显示，在执行任务时，精神分裂症患者使用了不同的注意力网络，背侧注意系统被激活，而对照组则激活了执行网络。此外，精神分裂症患者在执行任务时无法使后扣带回区域去激活，这支持了关于默认模式处理改变的最近的研究。这些发现支持了精神分裂症中大脑大范围网络功能失调募集的理论。
