Temasek Life Sciences Laboratory, National University of Singapore, Singapore 117604, Singapore.
Curr Opin Plant Biol. 2011 Feb;14(1):53-9. doi: 10.1016/j.pbi.2010.08.013. Epub 2010 Sep 24.
Floral homeotic genes encode transcription factors and act as master regulators of flower development. The homeotic protein complex is expressed in a specific whorl of the floral primordium and determines floral organ identity by the combinatorial action. Homeotic proteins continue to be expressed until late in flower development to coordinate growth and organogenesis. Recent genomic studies have shown that homeotic proteins bind thousands of target sites in the genome and regulate the expression of transcription factors, chromatin components and various proteins involved in hormone biosynthesis and signaling and other physiological activities. Further, homeotic proteins program chromatin to direct the developmental coordination of stem cell maintenance and differentiation in shaping floral organs.
花的同源异形基因编码转录因子，作为花发育的主要调控因子。同源异形蛋白复合物在花原基的特定轮中表达，并通过组合作用决定花器官的身份。同源异形蛋白一直表达到花发育的后期，以协调生长和器官发生。最近的基因组研究表明，同源异形蛋白结合基因组中的数千个靶位点，并调节转录因子、染色质成分和各种参与激素生物合成和信号转导及其他生理活动的蛋白质的表达。此外，同源异形蛋白对染色质进行编程，以指导干细胞维持和分化的发育协调，从而塑造花器官。
