CNRS, UMR, Rennes, France.
Chem Phys Lipids. 2010 Nov;163(8):794-9. doi: 10.1016/j.chemphyslip.2010.09.005. Epub 2010 Sep 24.
The synthesis of novel archaeal lipid analogues is described. The hydrophobic core of these tetraether bipolar lipids were based on a disubstituted 1,3-cyclopentane unit which was further equipped with mannosyl polar head groups. This hemimacrocylcic tetraether structure that can be compared to rare archaeal lipids permit to establish the behavior of such bipolar lipid at the air/water interface. The two oxygen atoms and the cyclopentane ring were found to be of importance on this behavior. Indeed, the air/water interface comparative study of tetraether- and diether-type lipids led to conclusions on a bent conformation of the tetraether at the air/water interface in the presence of a cyclopentane unit even if the presence of the two oxygen atoms favored an opened bent shape at the beginning of the compression.
描述了新型古菌脂类似物的合成。这些四醚双极性脂质的疏水区核心基于一个取代的 1,3-环戊烷单元，该单元进一步配备了甘露糖极性头基。这种半大环四醚结构可以与罕见的古菌脂相媲美，允许在空气/水界面上确定这种双极性脂质的行为。发现这两个氧原子和环戊烷环对这种行为很重要。事实上，对四醚型和醚型脂质的空气/水界面比较研究得出结论，即使存在两个氧原子有利于在压缩开始时形成开放的弯曲形状，在存在环戊烷单元的情况下，四醚在空气/水界面上呈弯曲构象。
