Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX 77843-4458, USA.
Mitochondrion. 2011 Jan;11(1):166-75. doi: 10.1016/j.mito.2010.09.005. Epub 2010 Oct 1.
Complete mitochondrial DNA (mtDNA) genomes from 43 bison and bison-cattle hybrids were sequenced and compared with other bovids. Selected animals reflect the historical range and current taxonomic structure of bison. This study identified regions of potential nuclear-mitochondrial incompatibilities in hybrids, provided a complete mtDNA phylogenetic tree for this species, and uncovered evidence of bison population substructure. Seventeen bison haplotypes defined by 66 polymorphic sites were discovered, whereas 728 fixed differences and 86 non-synonymous mutations were identified between bison and bison-cattle hybrid sequences. The potential roles of the mtDNA genome in the function of hybrid animals and bison taxonomy are discussed.
从 43 头野牛和野牛-牛杂交种中提取并测序了完整的线粒体 DNA（mtDNA）基因组，并与其他牛科动物进行了比较。所选动物反映了野牛的历史分布范围和当前分类结构。本研究在杂种中鉴定出了潜在的核-线粒体不相容区域，为该物种提供了完整的 mtDNA 系统发育树，并揭示了野牛种群亚结构的证据。在野牛和野牛-牛杂交种序列之间发现了 17 个由 66 个多态性位点定义的野牛单倍型，而确定了 728 个固定差异和 86 个非同义突变。讨论了 mtDNA 基因组在杂种动物和野牛分类学功能中的潜在作用。
