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Pressor effect of NG-monomethyl-L-arginine in SHRSP.

作者信息

Aisaka K, Mitani A, Kitajima Y, Ishihara T

机构信息

Laboratory of Experimental Pharmacology, Suntory Institute for Biomedical Research, Osaka, Japan.

出版信息

Jpn J Pharmacol. 1990 Dec;54(4):461-3. doi: 10.1254/jjp.54.461.

DOI:10.1254/jjp.54.461
PMID:2087008
Abstract

Pressor effects of NG-monomethyl-L-arginine (L-NMMA), a selective inhibitor of nitric oxide production from L-arginine, on mean blood pressure (MBP) were investigated in conscious Wistar Kyoto rats (WKY) and stroke-prone spontaneously hypertensive rats (SHRSP). L-NMMA (0.1-10 mg/kg, i.v.) elicited a dose-dependent increase in the MBP of WKY and SHRSP. The pressor response to L-NMMA was more marked in SHRSP than in WKY. These results suggest that nitric oxide may play an important role in the blood pressure regulation in the conscious SHRSP.

摘要

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