接种痘苗病毒的兔炎症皮肤提取物中的非蛋白质部分（神经妥乐平）对Meth A诱导的迟发型超敏反应的影响。
Effect of a non-protein fraction from an extract of the inflamed skin of rabbits inoculated with vaccinia virus (Neurotropin) on Meth A-induced delayed type hypersensitivity.
作者信息
Mori H, Kurimoto Y, Xu Q A, Koda A
机构信息
Department of Pharmacology, Gifu Pharmaceutical University, Japan.
出版信息
Jpn J Pharmacol. 1990 Dec;54(4):468-72. doi: 10.1254/jjp.54.468.
The effect of a non-protein fraction from an extract of inflamed skin of rabbits inoculated with vaccinia virus (Neurotropin, NSP) was studied on Meth A tumor-induced delayed type hypersensitivity (Meth A-DTH) in BALB/c mice. NSP enhanced the Meth A-DTH. NSP also enhanced the DTH suppressed with 5-fluorouracil (5-FU). Moreover, NSP inhibited the fatal effect of 5-FU and restored the decrease of body weight caused by 5-FU. However, NSP reduced partially but significantly the suppression of the tumor growth by 5-FU. NSP may be useful for cancer treatment in combination with chemotherapeutic agents, if NSP does not inhibit their antitumor activity.
研究了接种痘苗病毒的兔炎症皮肤提取物中的非蛋白质组分（神经妥乐平，NSP）对BALB/c小鼠中Meth A肿瘤诱导的迟发型超敏反应（Meth A-DTH）的影响。NSP增强了Meth A-DTH。NSP还增强了被5-氟尿嘧啶（5-FU）抑制的DTH。此外，NSP抑制了5-FU的致死作用，并恢复了由5-FU引起的体重下降。然而，NSP部分但显著地降低了5-FU对肿瘤生长的抑制作用。如果NSP不抑制化疗药物的抗肿瘤活性，那么它可能与化疗药物联合用于癌症治疗。
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