Department of Pediatric Hematology and Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Ultrasound Med Biol. 2010 Nov;36(11):1783-91. doi: 10.1016/j.ultrasmedbio.2010.08.001. Epub 2010 Sep 26.
We studied the role of global myocardial strain and strain rate in monitoring subclinical heart failure in a large group of asymptomatic long-term survivors of childhood cancer. Global strain (rate) parameters of survivors were compared with those in healthy controls and were related to conventional echocardiographic parameters, N-terminal-pro-natriuretic peptide (NT-pro-BNP) levels and clinical parameters. Two-dimensional (2-D) echocardiography was performed in 111 survivors and 107 healthy controls. Blood samples were taken from survivors to determine NT-pro-BNP levels. We showed that global myocardial strain, strain rate and time to peak systolic strain in asymptomatic survivors of childhood cancer were significantly lower compared with healthy controls (p values <0.0001) and were significantly related to several systolic and diastolic left ventricular parameters. Whether myocardial strain and strain rate are superior to conventional echocardiography in the early detection of subclinical heart failure needs to be explored in further longitudinal prospective studies.
我们研究了整体心肌应变和应变速率在监测一大群无症状的儿童癌症长期幸存者亚临床心力衰竭中的作用。将幸存者的整体应变（率）参数与健康对照组进行比较，并与传统超声心动图参数、N 末端脑钠肽前体（NT-pro-BNP）水平和临床参数相关联。对 111 名幸存者和 107 名健康对照者进行二维（2-D）超声心动图检查。从幸存者中抽取血样以测定 NT-pro-BNP 水平。我们发现，无症状的儿童癌症幸存者的整体心肌应变、应变速率和收缩期峰值应变时间明显低于健康对照组（p 值均<0.0001），并且与多个收缩和舒张左心室参数显著相关。心肌应变和应变速率是否优于传统超声心动图在亚临床心力衰竭的早期检测中，需要在进一步的纵向前瞻性研究中探索。
