Interdisciplinary Group of Molecular Immunopathology, Dermatology/Medical Immunology, University Hospital Charité, Charitéplatz 1, 10117 Berlin, Germany.
Cytokine Growth Factor Rev. 2010 Oct;21(5):365-79. doi: 10.1016/j.cytogfr.2010.08.002. Epub 2010 Sep 25.
Interleukin (IL)-22 is a member of the IL-10 cytokine family that is produced by special immune cell populations, including Th22, Th1, and Th17 cells, classical and non-classical (NK-22) NK cells, NKT cells, and lymphoid tissue inducer cells. This cytokine does not influence cells of the hematopoietic lineage. Instead, its target cells are certain tissue cells from the skin, liver and kidney, and from organs of the respiratory and gastrointestinal systems. The main biological role of IL-22 includes the increase of innate immunity, protection from damage, and enhancement of regeneration. IL-22 can play either a protective or a pathogenic role in chronic inflammatory diseases depending on the nature of the affected tissue and the local cytokine milieu. This review highlights the primary effects of IL-22 on its target cells, its role in the defense against infections, in tumorigenesis, in inflammatory diseases and allergy as well as the potential of the therapeutic modulation of IL-22 action.
白细胞介素 (IL)-22 是白细胞介素 10 细胞因子家族的一员，由特殊的免疫细胞群产生，包括 Th22、Th1 和 Th17 细胞、经典和非经典 (NK-22) NK 细胞、NKT 细胞和淋巴组织诱导细胞。这种细胞因子不会影响造血谱系的细胞。相反，它的靶细胞是来自皮肤、肝脏和肾脏以及呼吸系统和胃肠道器官的某些组织细胞。IL-22 的主要生物学作用包括增强先天免疫、防止损伤和促进再生。IL-22 在慢性炎症性疾病中可以发挥保护作用或致病作用，这取决于受影响组织的性质和局部细胞因子环境。这篇综述强调了 IL-22 对其靶细胞的主要作用、它在抗感染、肿瘤发生、炎症性疾病和过敏中的作用以及治疗性调节 IL-22 作用的潜力。
